Sökning: "co-expression network"

Visar resultat 16 - 19 av 19 avhandlingar innehållade orden co-expression network.

  1. 16. Neuromodulation shapes interneuron communication in the mouse striatum

    Författare :Matthijs Constantijn Dorst; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A proper understanding of cognition relies on detailed knowledge about the functional connectivity within and between brain areas. The striatum is generally regarded as the input structure to the basal ganglia, a group of subcortical nuclei that have been demonstrated to be involved in motor function and reward, amongst other functions. LÄS MER

  3. 17. Regulatory roles for long noncoding RNAs and circular RNAs in human skin wound repair

    Författare :Maria-Alexandra Toma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human skin wound repair is a multiphase process, which includes inflammation, growth and remodeling, and requires the concerted communication of many cell types. During the course of healing, skin cells find themselves in a hostile environment where processes like migration, differentiation, apoptosis and proliferation must be correctly executed in order to restore the integrity of the injured tissue. LÄS MER

  4. 18. Mechanisms of cell diversification

    Författare :Christopher Winston Uhde; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cell identity and function is determined by the intrinsic wiring of the gene regulatory network that endows progenitors with the competence to respond appropriately to extrinsic cues in a spatiotemporally-dependent manner. One such class of cues, morphogens, instruct cells in their identity by virtue of a concentration gradient, but how this is interpreted at gene regulatory levels to result in sharp and robust boundaries of gene expression is poorly understood. LÄS MER

  5. 19. At the intersection of proteomics and pathology : application of mass spectrometry-based protein quantification to histopathology and antibody validation

    Författare :Fabio Socciarelli; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The paradigm of Precision Medicine relies on the molecular stratification of patients to select “the right patient for the right drug”. The genomic approach has tried to answer this question, but large genomic studies have raised more questions than given answers. LÄS MER