Sökning: "MTNR1B"

Hittade 4 avhandlingar innehållade ordet MTNR1B.

  1. 1. Melatonin receptors in pancreatic islets - Linking a genetic variant to functional phenotype

    Författare :Cecilia Nagorny; Diabetes - molekylär metabolism; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melatonin receptor; knock out mice; IVGTT; OGTT; ITT; Hyperinsulinemic clamp; MTNR1B; MT2;

    Sammanfattning : Defective insulin secretion and insulin resistance are the two hallmarks of Type 2 Diabetes (T2D). The pathophysiology of the disease is not fully understood but genetic susceptibility for the disease is a new major player in the understanding of the underlying mechanisms. LÄS MER

  3. 2. Genetic association studies of symptoms, comorbidity and outcome in bipolar disorder and schizophrenia

    Författare :Dzana Sudic Hukic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Schizophrenia and bipolar disorder are complex brain disorders. Research has focused on applying brain research to understand the etiology, as well as clinical research to improve treatment, prognosis and progression. LÄS MER

  4. 3. The role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetes

    Författare :Tina Rönn; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene expression; oxidative phosphorylation; GWAS; SNP; DNA methylation; epigenetics; type 2 diabetes;

    Sammanfattning : The incidence of diabetes is increasing worldwide, with the most prevalent form being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. LÄS MER

  5. 4. Autoimmune diabetes in adults : epidemiological studies of risk factors and mortality

    Författare :Lisa Olsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Although autoimmune diabetes in adults is a common form of diabetes, knowledge on risk factors and long term consequences of the disease is limited. The aims of this thesis were to investigate the influence of socioeconomic factors (education and occupation), sleep disturbances and psychological well-being on the risk of developing autoimmune diabetes in adults, to investigate whether genetic variation in the melatonin receptor 1B (MTNR1B) contributes to the association between poor sleep and type 2 diabetes which has been previously suggested, and finally to investigate the risk of mortality from all causes, cardiovascular disease and ischemic heart disease in adult-onset autoimmune diabetes, with consideration of the possible influence of metabolic risk factors, glycaemic control, lifestyle factors and socioeconomic position. LÄS MER