Sökning: "autoimmune disorders"

Visar resultat 16 - 20 av 125 avhandlingar innehållade orden autoimmune disorders.

  1. 16. Development of immunomodulatory RNA therapeutics for immune disorders

    Författare :Vaishnavi Srinivasan Iyer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmune diseases such as Rheumatoid Arthritis (RA) are complex and involve many different cell types. Of these cell types, T cells are thought to be key drivers of the inflammation. LÄS MER

  3. 17. Characterization of Eae4 and Eae19-22 in autoimmune neuroinflammation

    Författare :Rita Nohra; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :QTL; EAE; MS; epistasis; AIL.;

    Sammanfattning : Multiple Sclerosis (MS) is the most common chronic inflammatory disorders of the central nervous system (CNS) with a prevalence of 1-211000 in the Northern European population. MS is caused by a combination of environmental factors and multiple genes. LÄS MER

  4. 18. Role of cytokines in experimental neurodegenerative and neuroinflammatory disorders

    Författare :Xing-Mei Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Altered expression of cytokines in response to body injury has diverse actions that can exacerbate, mediate, reduce or inhibit neuronal and myelin damage as well as influence the disease development in a variety of nervous system disorders, such as Alzheimer s disease (AD), multiple sclerosis and Guillain-Barré Syndrome (GBS). In these studies, we attempted to explore the possible roles of tumor necrosis factor (TNF)-α and interleukin (IL)-18 in experimental neurodegenerative and neuroinflammatory disorders. LÄS MER

  5. 19. Epigenetic and Gene Expression Signatures in Systemic Inflammatory Autoimmune Diseases

    Författare :Juliana Imgenberg-Kreuz; Gunnel Nordmark; Ann-Christine Syvänen; Johanna K Sandling; Amr Sawalha; Uppsala universitet; []
    Nyckelord :Autoimmunity; DNA methylation; Primary Sjögren’s syndrome; Systemic lupus erythematosus; Gene expression; Type I interferon system; Epigenetics; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Autoimmune diseases are clinical manifestations of a loss-of-tolerance of the immune system against the body’s own substances and healthy tissues. Primary Sjögren’s syndrome (pSS) and systemic lupus erythematosus (SLE) are two chronic inflammatory autoimmune diseases characterized by autoantibody production and an activated type I interferon system. LÄS MER

  7. 20. Understanding chronic immunodeficiency disorders through assessment of cytotoxic lymphocyte function

    Författare :Jakob Theorell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Representing an evolving and diverse group of syndromes, immunodeficiencies can currently be viewed as a spectrum of disorders where a dysfunction of the immune system plays a significant etiologic role. Cytotoxic lymphocytes are immune cells that are pivotal for the eradication of infected and malignant cells. LÄS MER