Sökning: "autoimmune disorders"

Visar resultat 21 - 25 av 125 avhandlingar innehållade orden autoimmune disorders.

1. 21. Positional identification and functional analysis of genes regulating autoimmune arthritis

   Författare :Anthony Chun Yeung Yau; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The major histocompatibility complex (MHC) is the most gene-dense and polymorphic region in the human genome with strong associations to many autoimmune disorders, including rheumatoid arthritis (RA). However, even the genetic association between MHC and RA was known more than 40 years ago, we still have not fully explained the functional roles of the MHC genes and identified the underlying specific polymorphisms. LÄS MER

3. 22. Multiplex HLA-DR-DQ genotyping : for genetic epidemiology and clinical risk assessment

   Författare :Ewa Lavant; Malmö högskola; []
   Nyckelord :HLA-DRB1; HLA-DQB1; HLA-DQA1; PCR-SSP; type 1 diabetes; celiac disease; autoimmune disease; capillary gel electrophoresis; genotyping;

   Sammanfattning : The human leukocyte antigens (HLA) are highly polymorphic cell surface proteins encoded in the major histocompatibility complex (MHC) region on chromosome 6. The HLA system has been well known as transplantation antigens but the primary biological role of the HLA molecules is regulation of immune response by presenting peptide fragments to T-lymphocytes. LÄS MER

4. 23. Vitiligo and Piebaldism : Treatmant of Leucoderma by Transplantation of autologous melanocytes

   Författare :Mats J. Olsson; Hugh Zachariae; Uppsala universitet; []
   Nyckelord :Medical sciences; leucoderma; leukoderma; vitiligo; piebaldism; melanocytes; pigmentation; cell culturing; serum-free; transplantation; surgery; autoimmune disease; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Dermatology and Venerology; dermatologi och venereologi;

   Sammanfattning : Background: Vitiligo and piebaldism are disorders in which the affected skin lack epidermal melanocytes. Vitiligo is acquired and can clinically be subgrouped, but the aetiology is still not fully understood. The most common type, generalized vitiligo (vitiligo vulgaris) has autoimmune involvement and affects about 1. LÄS MER

5. 24. Uncovering biomarkers and molecular heterogeneity of complex diseases : Utilizing the power of Data Science

   Författare :Sara Younes; Linda Holmfeldt; Jan Komoroski; Aedin Culhane; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complex Disease; Cancer; Autoimmune diseases; Acute Myeloid Leukemia; Systemic Lupus Erythematosus; Bioinformatics; Machine Learning; Data Science; Statistical Analysis; Bioinformatics; Bioinformatik; Computer Science; Datavetenskap;

   Sammanfattning : Uncovering causal drivers of complex diseases is yet a difficult challenge. Unlike single-gene disorders complex diseases are heterogeneous and are caused by a combination of genetic, environmental, and lifestyle factors which complicates the identification of patient subgroups and the disease causal drivers. LÄS MER

7. 25. Clinical and tumour biology studies of Diffuse Large B-cell Lymphoma : with emphasis on comorbidity, toxicity and outcome

   Författare :Charlott Mörth; Gunilla Enblad; Kristina Drott; Uppsala universitet; []
   Nyckelord :DLBCL; autoimmune disease; cardiac toxicity; neurotoxicity; EFS; OS; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Diffuse large B-cell lymphoma (DLBCL) is curable in around 70% when treated with standard immunochemotherapy R- CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone). Treatment related toxicity affecting survivors is a clinical problem as well as comorbidities influencing the possibility to give adequate treatment. LÄS MER