Sökning: "adrenal cortex"

Visar resultat 6 - 10 av 42 avhandlingar innehållade orden adrenal cortex.

  1. 6. In Vitro Studies of Adrenocorticolytic DDT Metabolites, with Special Focus on 3-methylsulfonyl-DDE

    Författare :Vendela Asp; Ingvar Brandt; Ulrika Bergström; Olle Söder; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicity; 3-methylsulfonyl-DDE; CYP; adrenal cortex; metabolic activation; steroid hormones; Y-1; H295R; mitotane; adrenocortical carcinoma; Toxicology; Toxikologi; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Sammanfattning : The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO2-DDE) is bioactivated by cytochrome P450 11B1 (CYP11B1) in the adrenal cortex of mice and forms irreversibly bound protein adducts, reduces glucocorticoid secretion, and induces cell death selectively in cortisol-producing adrenocortical cells. 3-MeSO2-DDE has therefore been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) therapy. LÄS MER

  3. 7. Cytochrome P-450 dependent monooxygenases in the mammalian adrenal cortex : properties and role in steroidogenesis and metabolism of polycyclic aromatic hydrocarbons

    Författare :Johan Montelius; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  4. 8. Metabolism and toxicity of polycyclic aromatic hydrocarbons in the rat adrenal cortex : a mechanism of action involving cytochrome P-450 and subcellular pools of glutathione

    Författare :Einar Hallberg; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  5. 9. Structure and function of the adrenal cortex in mice with the obese-hyperglycemic syndrome

    Författare :Peter Naeser; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  7. 10. Brain structure and function in primary adrenal insufficiency

    Författare :Annelies van't Westeinde; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Individuals with primary adrenal insufficiency (PAI), i.e., congenital adrenal hyperplasia (CAH) and autoimmune Addison’s disease (AAD), suffer from impaired production of the adrenal gland hormones cortisol and aldosterone, and in the case of AAD, also androgens. LÄS MER