Sökning: "adrenal cortex"

Visar resultat 11 - 15 av 42 avhandlingar innehållade orden adrenal cortex.

1. 11. Tumors of the adrenal glands : genetic and diagnostic aspects

   Författare :Fredrika Svahn; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Adrenal tumors have varying clinical presentation, malignancy rates and patient morbidity. Adrenal cortical carcinomas (ACCs) are malignant tumors originating from the adrenal cortex. LÄS MER

3. 12. Functional and structural studies on CYP21 mutants in congenital adrenal hyperplasia

   Författare :Tiina Robins; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Congenital adrenal hyperplasia; CAH; CYP21; enzyme activity; modeling; genotype phenotype relationships; structure function relationships.;

   Sammanfattning : Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is one of the most common autosomal recessive disorders, affecting around 1/10 000 newborns worldwide. A defect in the gene encoding steroid 21-hydroxylase, CYP21, results in impaired synthesis of cortisol and in most cases also aldosterone. LÄS MER

4. 13. Neurocognitive and endocrine dysfunction in women with exhaustion syndrome

   Författare :Agneta Sandström; Tommy Olsson; Lars Nyberg; Marie Åsberg; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cognition; attention; working memory; exhaustion syndrome; major depression; cortisol; HPA-axis; proinflammatory cytokines; psychology; neurocognitive; endocrine; fMRI; MRI; prefrontal cortex; multivariate; women; personality; TCI; stress; Public health medicine research areas; Folkhälsomedicinska forskningsområden; Diagnostic radiology; Diagnostisk radiologi; medicin; Medicine; diagnostisk radiologi; Diagnostic Radiology;

   Sammanfattning : Stress has emerged as one of the most important factors to consider in psychiatric diagnoses and has become a common reason for long-term sick leave (LTSL). Roughly 50% of LTSL due to psychiatric diseases are thought to be associated with work-related stress. LÄS MER

5. 14. Enzymatic Regulation of Steroidogenesis and Nuclear Receptor Activation : Special Focus on Vitamin D and Sex Hormones

   Författare :Johan Lundqvist; Kjell Wikvall; Maria Norlin; Magnus Ingelman-Sundberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adrenal steroidogenesis; CYP7B1; vitamin D; calcitriol; enzymatic regulation; transcriptional regulation; CYP21A2; aromatase; sex hormone; estrogen; androgen; nuclear receptor; Pharmaceutical biochemistry; Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

   Sammanfattning : Enzyme-catalyzed reactions are important to regulate steroidogenesis and nuclear receptor activation. The present investigation examines the role of steroid metabolism catalyzed by CYP7B1 for regulation of hormone receptor activation and the effects of vitamin D on enzymatic regulation of steroidogenesis. LÄS MER

7. 15. Differential effects of voluntary running on hippocampal plasticity in the adult rat brain

   Författare :Andrew Stuart Naylor; Göteborgs universitet; []
   Nyckelord :exercise; hippocampus; stress; progenitor proliferation; neurogenesis; trophic factors; frontal cortex; spatial memory; rat; pCREB; endogenous opioids;

   Sammanfattning : The continuation of neuronal birth from dividing neural stem cells in the dentate gyrus of the hippocampus throughout adulthood is known to play an important role in maintaining normal hippocampal function, such as memory and learning. Negative alterations in the levels of adult neurogenesis have also been linked to several neurodegenerative diseases, including Alzheimer s disease and mood disorders such as depression. LÄS MER