Sökning: "accelerated aging"

Visar resultat 11 - 15 av 56 avhandlingar innehållade orden accelerated aging.

  1. 11. The impact of diabetes on cognitive aging and dementia

    Författare :Anna Marseglia; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :prediabetes;

    Sammanfattning : The impact of prediabetes and diabetes on different stages of cognitive function during aging remains unclear. This thesis aimed to investigate the impact of prediabetes and of diabetes on cognitive aging—from cognitive deficits, through cognitive decline, to dementia—, explore underlying cerebral mechanisms and identify factors that may protect older adults with diabetes from dementia. LÄS MER

  3. 12. The effect of Plasmodium infection on cellular aging in humans

    Författare :Aurelie Miglar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Telomeres play an essential role in maintaining chromosomal integrity and stability. Telomere shortening is part of the natural aging process, nevertheless, accelerated telomere shortening has been linked to chronic diseases and premature aging. LÄS MER

  4. 13. Modeling and Testing of Insulation Degradation due to Dynamic Thermal Loading of Electrical Machines

    Författare :Zhe Huang; Industriell elektroteknik och automation; []
    Nyckelord :thermal degradation; thermal cycle; dynamic temperature; thermal-mechanical; fatigue; electrical insulation system; accelerated testing; condition monitoring; electrical machine; electrified vehicles;

    Sammanfattning : Electrical machines in electrified vehicles are subjected to dynamic loadings at different driving conditions, which results in dynamic temperatures. The aging of the Electrical Insulation System (EIS) in electrical machines is caused by these dynamic temperatures, namely high average temperatures and temperature cycles. LÄS MER

  5. 14. Cardiovascular health and brain aging : a population-based MRI study

    Författare :Yuanjing Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Deterioration of brain structure and cognitive function occurs as individuals reach advanced age. The former can be observed through various markers of cerebral small vessel disease on magnetic resonance imaging (MRI) scans and the later can be assessed by neuropsychological tests and clinical examinations. LÄS MER

  7. 15. Chronic kidney disease : a clinical model of premature vascular aging

    Författare :Lu Dai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Patients with chronic kidney disease (CKD) are prone to develop an accelerated vascular aging phenotype characterized by vascular calcification (VC), a major culprit of cardiovascular complications and premature death. While VC has been recognized as an active pathophysiologic process with involvement of specific mediators and effectors, the coexistence of traditional risk factors (i. LÄS MER