Sökning: "Patricia Clark"

Hittade 2 avhandlingar innehållade orden Patricia Clark.

1. 1. Pulling Force Studies of Secretory Protein Translocation into the Endoplasmic Reticulum

   Författare :Theresa Kriegler; Tara Hessa; Patricia Clark; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Co-translational translocation; Xbp1 arrest peptide; Translocon-associated protein TRAP complex; Prion protein; Insulin; Biochemistry; biokemi;

   Sammanfattning : More than 30% of human genes encode secretory or membrane proteins. Most secretory proteins are targeted to the Endoplasmic reticulum (ER) membrane via cleavable N-terminal signal sequences either in a co- or post-translational manner. They enter or cross the membrane using a protein translocating channel (translocon). LÄS MER

3. 2. Protein Folding Activity of the Ribosome and Its Implication in Prion Processes

   Författare :Yanhong Pang; Suparna Sanyal; Patricia L. Clark; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Protein folding; Prion disease; Antiprion drug; Competitive inhibition; PFAR; Amyloid; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : How the linear protein chains fold into their three-dimensional active conformation is one of the remaining puzzles of modern science. Other than molecular chaperones, ribosome - the cellular protein synthesis machinery, has also been implicated in protein folding. LÄS MER