Sökning: "USP14"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet USP14.

  1. 1. Potential New Drugs in Lymphoma

    Författare :Maryam Delforoush; Gunilla Enblad; Mattias Berglund; Christina Drott; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lymphoma; diffuse large B-cell lymphoma; DLBCL; picropodophyllin; PPP; J1; melflufen; prodrug; cancer therapeutics; alkylating agents; b-AP15; proteasome inhibitors; DUB inhibition; UCHL5; USP14;

    Sammanfattning : Lymphomas are malignant tumours arising from cells in the lymphatic system. They are classified as B-cell lymphomas, T-cell lymphomas and Hodgkin lymphoma (HL). Of the B-cell lymphomas, one of the most common is diffuse large B-cell lymphoma (DLBCL). LÄS MER

  3. 2. Structural, Dynamic and Functional Studies of USP14 : A Proteasome-Associated Deubiquitinating Enzyme Regulating Protein Degradation

    Författare :Johannes Salomonsson; Maria Sunnerhagen; Alexandra Ahlner; Eleonore von Castelmur; Pau Bernadó; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Ubiquitin-Specific Protease 14 (USP14) is a proteasome-associated deubiquitinating enzyme (DUB) involved in regulation of protein degradation and recycling of ubiquitin. USP14 consists of a Ubl domain connected to a USP domain via a flexible linker. LÄS MER

  4. 3. Mechanistic studies of a novel inhibitor of the ubiquitin-proteasome system

    Författare :Ellin-Kristina Hillert; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The ubiquitin-proteasome system (UPS) not only maintains cellular proteostasis, but plays an essential role in multiple vital cellular processes, including survival and growth. Proteasomal inhibitors, such as bortezomib, have been shown to have effective anti-cancer properties, verifying the UPS as a viable drug target in cancer treatment. LÄS MER

  5. 4. Identifying Essential Deubiquitinase Interactions and Targeting Protein Ubiquitination in Cancer

    Författare :Johannes Gubat; Padraig D´arcy; Stig Linder; Maria Turkina; Per Lindahl; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Deubiquitinase; b-AP15; Ubiquitin-proteasome system;

    Sammanfattning : Cancer is the second leading cause of death globally and is one of the most pressing health issues today. While significant advances have been made in cancer treatment, drug resistance and toxicity remain formidable obstacles to successful therapy. Thus, there is a need to find novel targets that pave the way for new cancer therapeutics. LÄS MER

  7. 5. Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs

    Författare :Xin Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy. Cancer drug resistance includes two broad categories: intrinsic and acquired. LÄS MER