Sökning: "Ubiquitin-proteasome system"

Visar resultat 1 - 5 av 46 avhandlingar innehållade orden Ubiquitin-proteasome system.

1. 1. The ubiquitin-proteasome system during proteotoxic stress

   Författare :Victoria Menéndez Benito; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ubiquitin; proteasome; green fluorescent protein GFP ; degradation; inhibitor; neurodegeneration; stress;

   Sammanfattning : The dual function of the ubiquitin-proteasome system in protein quality control and as a master regulator of vital cellular processes places the system in a delicate position. This might be particularly relevant under patho-physiological conditions such as endoplasmic reticulum stress, which provoke the accumulation of aberrant proteins. LÄS MER

3. 2. Functional studies of the ubiquitin proteasome system using GFP based reporters

   Författare :Kristina Lindsten; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ubiquitin; proteasome; green fluorescent protein GFP ; degradation; inhibitor; Gly-Ala repeat; neurodegencration; poly-Gln aggregates.;

   Sammanfattning : Ubiquitin-dependent proteasomal degradation is of paramount importance for cellular processes such as cell cycle progression, transcriptional regulation, apoptosis and disposal of misfolded and aberrant proteins. Moreover the ubiquitin-proteasome system is the main producer of peptides used by major histocompatibility complex class 1 for antigen presentation. LÄS MER

4. 3. The role of the ubiquitin-proteasome system in neurodegenerative disorders

   Författare :Lisette Gerridina Gezina Catharina Verhoef; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Degradation; green fluorescent protein GFP ; neurodegeneration; polyglutamine; proteasome; UBB 1; ubiquitin;

   Sammanfattning : Neurodegenerative disorders are a heterogeneous group of clinically and pathologically diverse diseases. The diseases are characterised by selective loss of neurons. in specific regions of the brain. The result is disruption of motor, sensory or cognitive systems, leading to severe disability of the patients. LÄS MER

5. 4. Mechanistic studies of a novel inhibitor of the ubiquitin-proteasome system

   Författare :Ellin-Kristina Hillert; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The ubiquitin-proteasome system (UPS) not only maintains cellular proteostasis, but plays an essential role in multiple vital cellular processes, including survival and growth. Proteasomal inhibitors, such as bortezomib, have been shown to have effective anti-cancer properties, verifying the UPS as a viable drug target in cancer treatment. LÄS MER

7. 5. Evaluation of the Endo-Lysosomal System and the Ubiquitin-Proteasome System in Neurodegenerative Diseases

   Författare :Simon Sjödin; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Parkinson’s disease; frontotemporal dementia; dysfunctional proteostasis; cerebrospinal fluid; mass spectrometry;

   Sammanfattning : Neurodegeneration is the process of neuronal cell loss where the symptoms will reflect the regions affected. Neurodegenerative disorders including Alzheimer’s disease (AD), Parkinson’s disease (PD) and frontotemporal dementia (FTD) are all characterised by an accumulation of protein aggregates suggesting impaired production or turnover of these proteins. LÄS MER