Sökning: "Tumor Classification"

Visar resultat 21 - 25 av 77 avhandlingar innehållade orden Tumor Classification.

  1. 21. Multimodal treatment of gastric cancer : assessment of tumor regression and the role of minimally invasive surgery

    Författare :Andrianos Tsekrekos; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The generally poor prognosis of advanced gastric cancer (AGC) has led to the development of multimodal therapeutic protocols in which surgery is combined with systemic treatment, perioperative chemotherapy being the preferred approach in Europe. In this context, there still are several issues that need to be addressed. LÄS MER

  3. 22. Tumor progression in the ovary and colon. The interaction of Wnt-signaling, transcription and formation of prostaglandins

    Författare :Katarina Rask; Göteborgs universitet; []
    Nyckelord :CCAAT Enhancer Binding Proteins C EBPs ; Wingless Wnt Wnt signaling pathway; Cyclooxygenases COXs ; colorectal cancer CRC ; epithelial ovarian cancer EOC ;

    Sammanfattning : Alterations in cell-cell adhesion, intracellular signaling and transcriptional regulation are common events during transformation of cells to the malignant phenotype. Different cellular defense mechanisms, e.g. inflammatory responses, mediated by prostaglandins, have also been associated with tumor development. LÄS MER

  4. 23. lmproving diagnosis of central nervous system tumours using genetic and epigenetic tools

    Författare :Thomas Olsson Bontell; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Histopathology; DNA methylation profiling; DNA methylation-based classification; Diffuse lower grade-glioma; Genomic analysis; Molecular biomarkers; Pediatric glioma;

    Sammanfattning : Brain tumor diagnostics has traditionally been based on histopathology stains. The introduction of immunohistochemistry stains resulted in improved ability to classify these often devastating tumors. The understanding of molecular markers in central nervous system tumors has improved substantially in recent decades. LÄS MER

  5. 24. Prognostic factors in colorectal cancer : studies of thymidylate synthase expression, mismatch repair protein expression, tumor budding and t-cell infiltration

    Författare :Mia Karlberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Colorectal cancer (CRC) is a major health problem in the Western world. CRC is treatable with surgery and often curable when the disease is diagnosed at an early stage. With improved surgery and adjuvant chemotherapy treatment, the disease-free-survival (DFS) rate for colon cancer is approximately 80% for stage II and for stage III close to 65%. LÄS MER

  7. 25. Pancreatic cancer : investigation of the prognostic significance of tumor immunophenotype and establishment of a novel ex-vivo tissue slice culture system for drug sensitivity testing

    Författare :Carlos Fernández Moro; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pancreatic ductal adenocarcinoma (PDAC), commonly referred to as pancreatic cancer, is associated with a dismal 5-year overall survival of 9 to 6 %. A major reason for the high mortality is the pronounced resistance to treatment. LÄS MER