Sökning: "Tuberculosis TB"

Visar resultat 16 - 20 av 109 avhandlingar innehållade orden Tuberculosis TB.

  1. 16. Helminths and immunity against tuberculosis

    Författare :Daniel Elias; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :tuberculosis; BCG; helminths; immunomodulation; vaccination;

    Sammanfattning : The efficacy of Bacille Calmette Guerin (BCG) is low and incidence of tuberculosis (TB) is high in those areas where helminths are endemic. Protection against tuberculosis requires strong cell mediated immunity while chronic helminth infections induce responses characterized by dominant Th2 responses as well as up-regulated regulatory T cell activity. LÄS MER

  3. 17. Immunological aspects of latent tuberculosis infection during pregnancy

    Författare :Fregenet Tesfaye Tegegn; Klinisk infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Interferon-γ; immune mediators; latent tuberculosis infection; Mtb-antigen reactivity; pregnancy; QuantiFERON-TB Gold Plus;

    Sammanfattning : Pregnancy-induced immune modulation might lead to reactivation of latent tuberculosis infection (LTBI). This thesis explores aspects of immune-based LTBI diagnostics and how pregnancy affects the immune control of Mycobacterium tuberculosis (Mtb) infection. We studied a prospective cohort of women recruited during pregnancy in Ethiopia. LÄS MER

  4. 18. Drug resistance in mycobacterium tuberculosis

    Författare :Getahun Abate; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Multidrug-resistance; tuberculosis; cefepime; moxicillin-clavulanate; ethambutol; WIT; rifampicin; isoniazid; katG;

    Sammanfattning : Drug-resistant tuberculosis is a global public health problem. This investigation was performed to find ways of improving regimens that could be used for the treatment of drug- and multidrug-resistant TB and also to find a rapid method of diagnosis of drug resistant TB, particularly MDR-TB. Among 107 isolates of M. LÄS MER

  5. 19. Pharmacometric Models to Improve Treatment of Tuberculosis

    Författare :Elin M Svensson; Mats O Karlsson; Maria C Kjellsson; Ulrika S H Simonsson; N. L’Ntshotsholé (Shasha) Jumbe; Uppsala universitet; []
    Nyckelord :pharmacokinetics; pharmacodynamics; population approach; nonlinear mixed-effects models; multidrug-resistant tuberculosis; bedaquiline; antiretroviral; drug-drug interactions; time-to-event; albumin; Klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Tuberculosis (TB) is the world’s most deadly infectious disease and causes enormous public health problems. The comorbidity with HIV and the rise of multidrug-resistant TB strains impede successful therapy through drug-drug interactions and the lack of efficient second-line treatments. LÄS MER

  7. 20. Towards individualised treatment of tuberculosis

    Författare :Katarina Niward; Thomas Schön; Jakob Paues; Judith Bruchfeld; Maria Lerm; Åse B. Andersen; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Each year, around 10 million of individuals develop active tuberculosis (TB). Worldwide, TB is the leading cause of death from an infectious agent surpassing both malaria and HIV. LÄS MER