Sökning: "Time-lapse microscopy"

Visar resultat 21 - 24 av 24 avhandlingar innehållade orden Time-lapse microscopy.

  1. 21. The role of cyclin E in cell cycle regulation and genomic instability

    Författare :Susanna Ekholm-Reed; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cyclin E; cell cycle; Restriction point; pre-RC; Mcm proteins; DNA replication; tumorigenesis; proteolysis; hCdc4;

    Sammanfattning : Cyclin E, a positive regulatory subunit of Cdk2, normally accumulates periodically at the G1/S transition, where it promotes entry into S phase and other DNA replication-associated functions. However, in many types of human cancer, cyclin E is overexpressed and in some cases its expression becomes deregulated, a phenomenon generally associated with poor prognosis. LÄS MER

  3. 22. Activation of human dendritic cells : role of the allergenic yeast Malassezia and NK cells

    Författare :Eva Buentke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Antigen-presenting cells; atopic eczema dermatitis syndrome; cytokines; dendritic cells; Malassezia; NK cells; yeast;

    Sammanfattning : Immature bone marrow derived dendritic cells (DCs) patrol the periphery of our body, where they encounter and take up foreign antigens. Once activated, DCs migrate to regional lymph nodes to present peptides derived from these antigens to naive T cells, and elicit different T helper (Th) cell responses. LÄS MER

  4. 23. Basement membrane collagens in pancreatic cancer : novel stroma-derived tumor markers and regulators of cancer cell growth

    Författare :Daniel Öhlund; Malin Sund; Peter Naredi; Matthias Löhr; Umeå universitet; []
    Nyckelord :Pancreatic cancer; tumor marker; basement membrane; type IV collagen; type XVIII collagen; matrix metalloproteinase; integrin; autocrine loop; tumor stroma; kirurgi; Surgery;

    Sammanfattning : Background: Among the common malignancies, pancreatic cancer has the shortest long-term survival. The aggressive, rapid, and infiltrative growth pattern of pancreatic cancer, together with the lack of specific symptoms, often leads to late diagnosis. LÄS MER

  5. 24. Cellular Effects of Cystatins

    Författare :Samar Hunaiti; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cystatin C; Cystatin D; Galectin-1; Puncta assay; HoloMonitor; Cancer cells; Apoptosis; Cathepsin C;

    Sammanfattning : The exact cellular functions of cystatins are still unknown, and the molecular mechanism leading to their internalization into cells is not yet fully understood. Commonly the cystatins are known to inhibit human lysosomal cysteine proteases (cysteine cathepsins) and it is supposed that this is their primary physiological role. LÄS MER