Sökning: "T Zhang"

Visar resultat 11 - 15 av 34 avhandlingar innehållade orden T Zhang.

  1. 11. Immunogenicity of and apoptosis modulation by Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP1) : implications for nasopharyngeal carcinoma

    Författare :Xiangning Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus which infects more than 90% of individuals in the population, and has been shown to be associated with a variety of human tumors. The viral genome encodes a number of transforming proteins which enable the virus to efficiently immortalize B lymphocyte and also transform cells of other types. LÄS MER

  3. 12. Molecular alterations and clonal evolution in acute myeloid leukemia : prognostic and therapeutic implications

    Författare :Xiaolu Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic stem cells characterized by inhibition of differentiation, subsequent accumulation of incomplete matured cells at various stages and reduced production of healthy hematopoietic elements. Despite significant progress, the outcome of AML is variable and often suboptimal. LÄS MER

  4. 13. Structural studies of lumazine synthases : thermostability, catalytic mechanism and molecular assembly

    Författare :Xiaofeng Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :X-ray crystallography; lumazine synthase; thermostability; catalytic mechanism; molecular assembly;

    Sammanfattning : Riboflavin, also known as vitamin B2, is biosynthesized in plants, bacteria, archaea and fungi. The primary biological function of riboflavin is related to its existence as a component of the two coenzymes, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which play an important role for electron transfer in energy metabolism. LÄS MER

  5. 14. Brain MRI and CT morphology in healthy aging and Alzheimer's disease

    Författare :Yi Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer disease; Brain; Atrophy; Diagnosis; CSF; CT; MRI; vascular risk factors; population-based study;

    Sammanfattning : Background: The brain atrophy in individual Alzheimer's disease (AD) patients includes not only specific atrophy from AD pathology, but also atrophy induced by normal aging and cerebral vascular diseases. Although medial temporal lobe atrophy (MTA) together with CSF biomarkers is suggested to be the most important diagnostic markers for AD, it may not be specific. LÄS MER

  7. 15. Pro-senescence therapy by targeting MYC and its network as a strategy to combat cancer

    Författare :Fan Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is defined as abnormal cell proliferation with the potential of metastasis and is an increasing threat to global health as the population becomes older. Cancer is triggered by gain-of-function mutations in oncogenes and loss of function mutations in tumor suppressor genes. LÄS MER