Sökning: "Serotonin class 2 receptor antagonist"

Hittade 2 avhandlingar innehållade orden Serotonin class 2 receptor antagonist.

  1. 1. Tissue remodelling in pulmonary fibrosis linked to 5-HT2 receptor activation

    Författare :Anna Löfdahl; Lungbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Serotonin 5HT ; Serotonin class 2 receptor antagonist; Fibroblast; Pulmonary fibrosis; Extracellular matrix ECM ;

    Sammanfattning : After an injury, an immediate reparative response is triggered to replace the damaged tissue, however, in fibrosis, cells remain active despite wound resolution causing a steady build-up of fibrotic tissue. In pulmonary fibrosis,there is a constant regeneration and remodelling of lung tissue where the thin architecture of alveoli become thickened, hampering efficient diffusion of oxygen, as seen in diseases like idiopathic pulmonary fibrosis (IPF). LÄS MER

  3. 2. Development of novel serotonin 5-HT6 and dopamine D2 receptor ligands and MAO A inhibitors - Synthesis, structure-activity relationships and pharmacological characterization

    Författare :Cecilia Mattsson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; dopamine D2 receptor; serotonin reuptake transporter; monoamine oxidase; 5-HT6 receptor; DOPAC; 5-HIAA; 3-tetrahydropyridine indole; 3-piperidine indole; 3- pyrrolidin-1-ylmethyl chromen-2-one; dopamine D2 receptor;

    Sammanfattning : It is known since the 1950s that enhancement of the levels of the monoamines dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) in the brain will relieve the symptoms of major depression, and current therapies are still based on this mechanism. However, all available antidepressants today are still suffering from slow onset of therapeutic action, as well as adverse effects and lack of efficacy. LÄS MER