Sökning: "Rebecca Faresjö Melander"

Hittade 1 avhandling innehållade orden Rebecca Faresjö Melander.

1. 1. Factors influencing transferrin receptor-mediated brain delivery : Evaluating preclinical antibody-based proteins for PET imaging in Alzheimer’s disease

   Författare :Rebecca Faresjö Melander; Stina Syvänen; Dag Sehlin; Robert Thorne; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; brain delivery; bispecific antibody; transferrin receptor; Alzheimer s Disease; amyloid-beta; aging; single domain antibody; PET; Biofarmaci; Biopharmaceutics; Neurology; Neurologi; Molekylär medicin; Molecular Medicine; Biofarmaci; Biopharmaceutics;

   Sammanfattning : Antibody-based proteins targeting amyloid-beta (Aβ) could be used as radioligands in positron emission tomography (PET) to study Alzheimer’s disease (AD) pathology in the living brain. The prospective advantages of antibody-based PET are to detect pathology earlier, with higher sensitivity, and to evaluate treatment effects of emerging immunotherapies against Aβ. LÄS MER