Sökning: "RBP"

Visar resultat 11 - 15 av 22 avhandlingar innehållade ordet RBP.

  1. 11. Sarcoma ecosystems : spatial characterization and prognostic significance

    Författare :Yanhong Su; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sarcoma is a highly heterogeneous disease with complex biological activities and unique tumor microenvironments (TME) in distinct subtypes. The limited treatment options and inadequate responses to current therapies necessitate a deeper understanding of sarcoma biology and personalized treatment strategies. LÄS MER

  3. 12. Notch signalling in carcinogenesis : With special emphasis on T-cell lymphoma and colorectal cancer

    Författare :Jonas Ungerbäck; Peter Söderkvist; Ola Hermanson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Notch signalling; T-cell lymphoma; colorectal cancer; Wnt signalling; transcription; Medical cell biology; Medicinsk cellbiologi;

    Sammanfattning : The Notch signalling pathway is an evolutionary conserved pathway, named after the Notch receptors, Notch1-4 in mammals, which upon cell-cell contact and ligand binding releases the intracellular domain (NICD). NICD translocates into the nucleus where it binds the transcriptional repressor RBP-Jk, which together with co-activators belonging to the Mastermind-like family of proteins form a transcriptional activation complex. LÄS MER

  4. 13. Vitamins, fatty acids, physical activity and peak bone mass

    Författare :Magnus Högström; Peter Nordström; Anna Nordström; Jon Karlsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; physical activity; vitamin A; vitamin D; fatty acids; peak bone mass; males; Orthopaedics; Ortopedi;

    Sammanfattning : Osteoporosis is a disease characterized by low bone mineral density, deteriorated bone microstructure and increased fracture risk. About 50% of all women and 25% of all men will have an osteoporotic fracture. Given that there is no effective cure in established osteoporosis, prevention is of high importance. LÄS MER

  5. 14. Molecular aspects of retinol uptake and activation

    Författare :Martin Lidén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Retinoids (vitamin A derivatives) are essential for a wide variety of physiological processes, including embryonic development, growth, vision, reproduction, and maintenance of various epithelia and the immune system. 11-Cis-retinal serves as the chromophore of the visual pigments in the retina, whereas the hormonal retinoids, all-trans and 9-cis retinoic acid (RA), regulate the non-visual functions via activation of nuclear retinoid receptors (RARs and RXRs). LÄS MER

  7. 15. Structural Studies of Binding Proteins: Investigations of Flexibility, Specificity and Stability

    Författare :Ulrika Magnusson; Sherry L. Mowbray; Anthony J. Wikinson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Periplasmic binding protein; X-ray crystallography; conformational change; acidophile; protein specificity; protein structure; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Binding proteins are present both in gram-negative and gram-positive bacteria. They are the recognition components of the ABC transport systems that transport different nutrients into the cell, and are in some cases also involved in chemotaxis. LÄS MER