Sökning: "Nuclear receptor"

Visar resultat 11 - 15 av 376 avhandlingar innehållade orden Nuclear receptor.

  1. 11. Nuclear receptor and Wnt function in developing dopaminergic neurons

    Författare :Kyle Matthew Sousa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The progressive degeneration of dopaminergic neurons in the substantia nigra is one of the major pathological events associated with Parkinson’s Disease. Dopaminergic (DA) cell replacement therapy has emerged in recent years as a possible approach towards treating Parkinsonism. LÄS MER

  3. 12. Modulation of nuclear receptor signaling by RBR ubiquitin ligases

    Författare :Nina Gustafsson Sheppard; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nuclear receptors (NRs) constitute a superfamily of transcription factors and play important roles in physiology. Transcriptional regulation by NRs can be modulated through interactions with various coregulators that activate or repress transcription through mediating receptor and chromatin modifications as well as communicating with the general transcription factor machinery. LÄS MER

  4. 13. Modulation of nuclear receptor activity by a unique class of corepressors

    Författare :Elin Holter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nuclear receptors; corepressors; transcription; intracellular localization.;

    Sammanfattning : Nuclear receptors comprise a unique family of transcription factors that are crucial regulators of gene expression involved in diverse physiological and developmental processes. The nuclear receptor field has undergone a very rapid development during the recent two decades due to the recognition of the importance of nuclear receptors as intracellular signal transmitters and pharmaceutical targets. LÄS MER

  5. 14. Mechanisms behind growth of castration-resistant prostate cancer bone metastases

    Författare :Emma Jernberg; Pernilla Wikström; Jack Schalken; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; castration-resistance; bone metastases; androgen receptor; intratumoral steroidogenesis; androgen receptor splice variants; androgen receptor amplification; patologi; Pathology;

    Sammanfattning : Background: The first-line treatment for patients with advanced prostate cancer (PC) is androgen deprivation therapy. This therapy is initially effective, but after some time tumors relapse, predominantly within the bone, and are then termed castration-resistant prostate cancer (CRPC). LÄS MER

  7. 15. Molecular basis of estrogen receptor antagonism

    Författare :Nina Heldring; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen Receptor; antagonism; receptor signaling; phytoestrogen and conformational changes;

    Sammanfattning : Estrogen Receptors (ERs), ERα and ERβ, are responsible for mediating the physiological effects of the steroid hormone 17b-estradiol and structurally related compounds. ER signaling is a complex process where the combined effects of accessory proteins, known as coregulators, promoter characteristics and influence from other signaling systems, determine the cell-specific transcriptional response in a given situation. LÄS MER