Sökning: "intracellular localization."

Visar resultat 1 - 5 av 117 avhandlingar innehållade orden intracellular localization..

  1. 1. Towards subcellular localization of the human proteome using bioimaging

    Författare :Charlotte Stadler; Emma Lundberg; Carolina Wählby; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibody; antibody validation; automated image analysis; automated microscopy; cell line; confocal microscopy; fixation; green fluorescent protein GFP ; immunofluorescence IF ; organelle; protein expression; siRNA; subcellular localization;

    Sammanfattning : Since the publication of the complete sequence of the human genome in 2003 there has been great interest in exploring the functions of the proteins encoded by the genes. To reveal the function of each and every protein, investigation of protein localization at the subcellular level has become a central focus in this research area, since the localization and function of a protein is closely related. LÄS MER

  3. 2. Fungal Lectins. Molecular structure and function of a member of a novel lectin family

    Författare :Stefan Rosén; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; possible functions; expression; localization; binding specificities; primary and secondary structure; Agaricus bisporus; Arthrobotrys oligospora; Fungi; novel lectin family; Biology; Biologi;

    Sammanfattning : Lectins defined as non-enzyme, non-immunoglobulin carbohydrate binding proteins, have been found in a wide variety of viruses, bacteria, fungi, plants and animals. Although lectins have been purified from more than 60 different species of fungi, the structure and biological functions of these proteins are not well known. LÄS MER

  4. 3. Nephrin cellular trafficking and intracellular interactions

    Författare :Xiao Li Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nephrin; signal; missense mutations; trafficking.;

    Sammanfattning : Nephrin is a 180-kDa transmembrane glycoprotein belonging to the immunoglobulin family of cell adhesion molecules. Nephrin has an extracellular part with eight Ig-like motifs, one fibronectin-like domain, a transmembrane region and a short cytoplasmic tail. LÄS MER

  5. 4. Host control of intracellular bacterial infections

    Författare :Emma Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Listeria monocytogenes; CD44; flagellin; Chlamydia pneumoniae; TLR; NOD; IFNalpha beta; IFN-gamma;

    Sammanfattning : In this thesis various immune mechanisms regulating control of infections with the intracellular bacteria Listeria monocytogenes and Chlamydia pneumoniae have been studied. These bacteria infect macrophages in which they can successfully grow. However, macrophages are potent killers of intracellular bacteria. LÄS MER

  7. 5. Mechanisms of the intracellular survival of Francisella tularensis

    Författare :Linda Tancred; Anders Sjöstedt; Jean Celli; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; Igl; MglA; J774; IFN-γ; RNS; ROS; phagosome; Clinical bacteriology; Klinisk bakteriologi; mikrobiologi; Microbiology;

    Sammanfattning : Francisella tularensis is a gram-negative, highly virulent, intracellular bacterium which causes the zoonotic disease tularemia. The subspecies tularensis and holarctica are clinically important, and the former is the more virulent. The intracellular lifestyle of F. LÄS MER