Sökning: "NSCLC"

Visar resultat 36 - 40 av 46 avhandlingar innehållade ordet NSCLC.

  1. 36. Targeting Gb3 and apoptosis-related proteins to overcome cisplatin resistance

    Författare :Andreas Tyler; Kjell Grankvist; Simon Ekman; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cisplatin resistance; exosomes; gb3; HSP70; the Bcl-2 family; cell research; cellforskning; Medical Cell Biology; medicinsk cellbiologi; onkologi; Oncology;

    Sammanfattning : Background Cisplatin is used for treatment of malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) but treatment with cisplatin often leads to acquired resistance to cisplatin, resulting in poor patient survival. Globotriaosylceramide (Gb3) and multidrug resistance protein 1 (MDR1) have been associated with cisplatin resistance. LÄS MER

  3. 37. Nuclear medicine imaging of lung cancer and esophagus cancer

    Författare :Gunnar Herlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Lung cancer;

    Sammanfattning : Background: Somatostatin receptors (SSTRs) occur in cancer tissue, and 99mTc-depreotide is a labelled somatostatin receptor analogue, binding to SSTRs subtype 2, 3, and 5. Purpose: The general aim of the present thesis was to study somatostatin receptor scintigraphy (SSTRS) with 99mTc-depreotide in the diagnosis and characterization of cancers in the lung and oesophagus. LÄS MER

  4. 38. Studies of cell migration and matrix protease production in human lung cancer cell lines

    Författare :Cecilia G Bredin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Lung cancer; extracellular matrix; growth factors; matrix metalloproteases; integrins; migration; invasion;

    Sammanfattning : Metastatic spread in cancer is a complex multistep process involving continuous, sequential interactions between tumour cells and their respective microenvironment. Invasiveness per se has not been studied in this thesis, only some of its major components, such as cell migration and matrix protease production. LÄS MER

  5. 39. Molecular characterization of estrogen receptor beta variants : cancer cell proliferation and invasion

    Författare :Li Xu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogen plays crucial roles in the pathogenesis of breast cancer. Most of the known effects of estrogen signaling are mediated by estrogen receptors (ERs), ERα and ERβ. ERα is explored for breast cancer molecular classification and is a target of endocrine therapy. LÄS MER

  7. 40. At the intersection of proteomics and pathology : application of mass spectrometry-based protein quantification to histopathology and antibody validation

    Författare :Fabio Socciarelli; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The paradigm of Precision Medicine relies on the molecular stratification of patients to select “the right patient for the right drug”. The genomic approach has tried to answer this question, but large genomic studies have raised more questions than given answers. LÄS MER