Sökning: "Morris water maze"

Visar resultat 26 - 30 av 30 avhandlingar innehållade orden Morris water maze.

  1. 26. The hippocampal opioid system : role in spatial learning

    Författare :Johan Sandin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :opioid; dynorphin; nociceptin; hippocampus; learning; memory; acetylcholine; HPLC; microinjections;

    Sammanfattning : The main aim of the present thesis was to study the role of the endogenous hippocampal opioid system, and in particular, the role of dynorphin B and nociceptin, in spatial learning. The effects of bilateral infusion (using chronic cannulae) of dynorphin B into the dorsal hippocampus (CA3-region), an area containing a high number of dynorphin-containing neurons, were examined in the Morris swim-maze, a spatial task dependent on hippocampal functioning. LÄS MER

  3. 27. Amyloid precursor protein : cellular studies and animal models

    Författare :Tatjana Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by a number of neuropathological features, including extracellular deposits composed primarily of amyloid-β (Aβ) peptides. Aβ is derived from proteolysis of the amyloid precursor protein (APP) by consecutive action of β and γ-secretases. LÄS MER

  4. 28. An animal model of sport related concussive brain injury

    Författare :Hayde Bolouri; Göteborgs universitet; []
    Nyckelord :animal model; football; concussion; brain injury; neuropathology; cognitive function;

    Sammanfattning : A new animal model for concussion of the type seen in professional football was developed, since current animal models did not simulate these conditions. The model is characterized by a high velocity-low mass impact to the head of a freely moving object. Structural damages and functional effects of the model have been investigated. LÄS MER

  5. 29. Estrogen signaling in stroke : genetic and experimental studies

    Författare :Magnus Strand; Tommy Olsson; Jan Hillert; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; intracerebral hemorrhage; ischemic stroke; genetics; ERα; OPG; 17β-estradiol; enriched environment; learning and memory; hippocampus; NGFI-A; Medicine; Medicin;

    Sammanfattning : Stroke is a common and multifactorial disease influenced by genetic and environmental risk factors. It is a highly heterogeneous entity consisting of two main types, ischemic (80%) and hemorrhagic (20%) stroke. The most common form of hemorrhagic stroke is intracerebral hemorrhage (ICH). LÄS MER

  7. 30. Amyloid precursor protein with the Alzheimer´s disease 670/671 mutation : animal and cellular models

    Författare :Ewa Kloskowska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The amyloid precursor protein (APP) and it s derivatives play a key role in the pathogenesis of Alzheimer s disease (AD), which is characterized by the presence of multiple aggregates of an APP proteolytic product, Ab, and tau protein in the brains of affected patients. Clinically the disease is manifested by a progressive loss of memory and executive functions. LÄS MER