Sökning: "Mendelian Randomization Analysis"

Visar resultat 11 - 15 av 17 avhandlingar innehållade orden Mendelian Randomization Analysis.

  1. 11. Lipid-related genes and their associations with coronary heart disease

    Författare :Ci Song; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Coronary heart disease (CHD) is a complex disease caused by the long-term progression of atherosclerosis. Lipids, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) are well established biomarkers for CHD, and are used to predict individual 10-year risk for CHD both in the Framingham risk score and in the System for Cardiac Operative Risk Evaluation (SCORE) project. LÄS MER

  3. 12. Genetic predisposition and dietary factors in relation to adiponectin and insulin resistance

    Författare :He Gao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes mellitus is a global health problem, owing to the high prevalence and enormous associated economic burden. Insulin resistance is a critical condition to the development of type 2 diabetes (T2D). Adiponectin, a hormone secreted by the adipose cells, has attracted much attention for its insulin-sensitizing and anti-diabetic effects. LÄS MER

  4. 13. Genetics and biomarkers of frailty : towards individualized management of the frailty syndrome

    Författare :Ka Long Jonathan Mak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Frailty is an age-related, dynamic state of multisystem physiological decline and is a strong predictor of disability and mortality. To move towards an individualized management of frailty, a better understanding of its biological underpinnings and an early identification of frail older adults are necessary. LÄS MER

  5. 14. The gut-brain axis in Parkinson’s disease : epidemiological studies on causes, underlying mechanisms and novel treatments

    Författare :Xiaoying Kang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson’s disease (PD) is an age-related neurodegenerative disease with highly heterogeneous symptomatology. Little is known about why PD occurs. The gastrointestinal tract has been postulated as an origin of PD pathology, which then spreads along the gut- brain axis to enter the brain. LÄS MER

  7. 15. A short story of the long telomere : evidence in aging epidemiology

    Författare :Yiqiang Zhan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Telomeres are the sequences of nucleotides at the end of chromosomes. Each time a cell divides, telomeres become shorter. The length of telomeres can be replenished by an enzyme, telomerase. Telomere shortening is hypothesized as the biological origin of aging. LÄS MER