Sökning: "Ligand Design"
Visar resultat 11 - 15 av 167 avhandlingar innehållade orden Ligand Design.
11. Design, Synthesis, Mechanistic Rationalization and Application of Asymmetric Transition-Metal Catalysts
Sammanfattning : This thesis describes mechanistic studies, rational ligand design, and synthesis of asymmetric transition metal catalysts. The topics addressed concerned [Papers I-VII]:[I] The asymmetric addition of diethyl zinc to N-(diphenylphosphinoyl)benzalimine catalyzed by bicyclic 2-azanorbornyl-3-methanols was studied. LÄS MER
12. Molecular basis for galectin-ligand interactions : Design, synthesis and analysis of ligands
Sammanfattning : Galectins are a class of β-galactoside-binding proteins that bind glycoconjugates and have been implicated in cancer, regulation of immunity and inflammation. Design and synthesis have achieved highly potent and selective galectin ligands that can inhibit interactions with glycoproteins and have consequent cellular effects. LÄS MER
13. On the estimation of ligand binding affinities
Sammanfattning : A method to accurately estimate the binding affinity of a small molecule to a receptor would be indispensable in numerous fields. For instance, most drugs exert their action by binding to a macromolecule target. Thus, a lot of time and resources could be saved in drug design by predicting affinities by computer programs. LÄS MER
14. Design and synthesis of rhodium and iridium bis-η2 diolefin catalysts: : Applications in C–C bond formation and asymmetric catalysis
Sammanfattning : This thesis deals with the design and synthesis of rhodium and iridium bis-η2 diolefin catalysts and their applications in C–C bond formation and asymmetric catalysis.More specifically, the second chapter describes the development of inter- and intramolecular (5+2) cycloadditions catalyzed by cationic iridium(I) complexes that lead to the formation of seven-membered rings in a single step. LÄS MER
15. Design, Synthesis and Properties of Bipyridine-capped Oligothiophenes for Directed Energy and Electron Transfer in Molecular Electronic Applications
Sammanfattning : The earliest landmark in computer technology was construction of the Electronic Numerial Integrator and Computer, ENIAC. Computational switching was performed with vacuum tubes and relays, rather large in size, making this computer rather unwieldy. LÄS MER