Sökning: "KI serotonin"

Visar resultat 11 - 15 av 143 avhandlingar innehållade orden KI serotonin.

  1. 11. Neuropharmacological studies of Parkinson's disease with some emphasis on serotonin transmission

    Författare :Xiaoqun Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by hypokinesia, rigidity, tremor, gait disturbances and depression. There is an accumulative of protein aggregates, Lewy bodies, which appear to begin in the brainstem and progress caudorostrally. LÄS MER

  3. 12. Temporomandibular joint pain, hyperalgesia and allodynia in relation to interleukin-1ß and serotonin

    Författare :Per Alstergren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Arthritis; Human; Hydroxocobalamin; Hyperalgesia; Inflammation; Interleukin-1; Pain; Plasma; Serotonin; Synovial fluid; Temporomandibular joint; Vitamin B12;

    Sammanfattning : This thesis had two main aims and comprises a methodological and a clinical part. The aims were to develop a temporomandibular joint (TMJ) synovial fluid (SF) sampling method that enables the determination of the true SF level of various substances and, by using the developed TMJ SF sampling method, investigate the hypothesis that circulating as well as SF content of interleukin-1ß (IL-1ß) and serotonin (5-HT) influence different TMJ pain entities and signs of tissue destruction in patients with TMJ inflammatory disorders. LÄS MER

  4. 13. PET studies of the serotonin system in major depression and its treatment

    Författare :Mikael Tiger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The serotonin system has been implicated in major depression since the 1960s, mainly based on the serotonin enhancing properties of antidepressants. Positron emission tomography, PET, is the in vivo molecular imaging method with the best spatial resolution. LÄS MER

  5. 14. The serotonin receptor type 3 in chronic and experimental human muscle pain

    Författare :Nikolaos Christidis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :5-HT3 receptor; Granisetron; Human muscles; Muscle biopsy; Pain; Pressure pain threshold; Visual Analogue Scale; Randomized Controlled Double-blind Trial;

    Sammanfattning : The main aim of this thesis was to gain a better understanding of the influence of serotonin on chronic craniofacial muscle pain. The thesis comprised a basic science part and a human experimental part. LÄS MER

  7. 15. PET studies of the serotonin system in relation to behavioral phenotypes in psychiatry

    Författare :Ämma Tangen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Behavioral phenotypes beyond core symptoms of diagnoses have become an area of high interest in psychiatric research. All major psychiatric diagnoses are associated with deficits in cognitive function, including impairments in social abilities, which contribute to great suffering and have a negative impact on the everyday life. LÄS MER