Sökning: "Inactivation Pathway"
Visar resultat 1 - 5 av 82 avhandlingar innehållade orden Inactivation Pathway.
1. Stability and inactivation mechanisms of two transaminases
Sammanfattning : In the past decades, more and more enzymes are employed as biocatalysts in industrial processes because of their advantages, such as high efficiency, substrate selectivity and stereoselectivity. Among them, amine transaminases (ATAs) are pyridoxal 5’-phosphate (PLP) dependent enzymes. LÄS MER
2. Voltage sensor activation and modulation in ion channels
Sammanfattning : Voltage-gated ion channels play fundamental roles in neural excitability, they are for instance responsible for every single heart beat in our bodies, and dysfunctional channels cause disease that can be even lethal. Understanding how the voltage sensor of these channels function is critical for drug design of compounds targeting neuronal excitability. LÄS MER
3. Pharmacological targeting of p53 pathway alterations in tumors
Sammanfattning : The p53 tumor suppressor plays an important role in cell fate decisions upon diverse stress conditions. In response to stress, p53 functions as a transcription factor, activating transcription of a variety of its target genes responsible for several cellular responses, most importantly cell cycle arrest and apoptosis. LÄS MER
4. Targeting of the Myc pathway as a novel approach for cancer therapy
Sammanfattning : As transcription factors, Myc-family proteins function upstream of signaling pathways and regulate cell proliferation, differentiation, angiogenesis, apoptosis and transformation. Precisely regulated Myc expression is critical for cellular physiology, while perturbations of Myc expression have detrimental consequences to the organism. LÄS MER
5. Identification of tumor suppressor genes using the approach of gene inactivation test
Sammanfattning : Epithelial cancers are the most prevalent and lethal diseases in the world. They cause more than 80% of all cancer deaths. Development of these tumors is a complex process involving more than 100 genes from different chromosomes. We know that human chromosome 3 (chr. LÄS MER
