Sökning: "Inactivated"

Visar resultat 26 - 30 av 159 avhandlingar innehållade ordet Inactivated.

  1. 26. Shedding light on the STAT3 small molecule inhibitor field

    Författare :Sander Busker; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : STAT3 is one of the seven family members of the STAT transcription factor family. STAT3 has become a very attractive target for cancer therapy and other diseases. It has a prominent role in cancer development as well as progression. However, there are still no STAT3 inhibitors applied in the clinic. LÄS MER

  3. 27. Characterization of candidate disease genes from human chromosomes 11g13 and 22q

    Författare :Darek Kedra; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Fugu rubripes; 11q13 region; MEN1; menin; GCK; DMPKL; meningioma; clathrin; adaptin; NIPSNAP; synaptogyrin; TOM1; SMARCB1;

    Sammanfattning : Two regions of the human genome, 11q13 and 22q, have been shown to harbor numerous disease-related genes, among them tumor suppressor genes (TSGs). The aim of this project was to construct transcription maps within these chromosomal segments, and thus provide a basis for further analysis of some of the genes for their involvement in disease-related processes. LÄS MER

  4. 28. Molecular evolutionary studies of genome degradation in bacteria

    Författare :Jan O. Andersson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The genus Rickettsia belongs to the α-proteobacteria and consists of obligate intracellular bacteria, which often are pathogenic for humans. All Rickettsia have small genomes, highly adapted to an intracellular lifestyle. LÄS MER

  5. 29. The atypical Rho GTPase RhoD and its role in cellular dynamics

    Författare :Magdalena Blom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite its discovery 20 years ago, the accumulated knowledge about the Rho member RhoD is scarce. Instead, the vast majority of studies concerning Rho GTPases has focused on the three classical members RhoA, Cdc42 and Rac1. In contrast, RhoD is considered an atypical Rho GTPase, with an aberrant GTP/GDP cycling and an unknown regulation. LÄS MER

  7. 30. Stability and inactivation mechanisms of two transaminases

    Författare :Shan Chen; Per Berglund; Patrick Adlercreutz; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Amine Transaminase; Operational Stability; Inactivation Pathway; Enzyme Unfolding; Phosphate Group Binding Cup; Bioteknologi; Biotechnology;

    Sammanfattning : In the past decades, more and more enzymes are employed as biocatalysts in industrial processes because of their advantages, such as high efficiency, substrate selectivity and stereoselectivity. Among them, amine transaminases (ATAs) are pyridoxal 5’-phosphate (PLP) dependent enzymes. LÄS MER