Sökning: "Inactivated"

Visar resultat 16 - 20 av 159 avhandlingar innehållade ordet Inactivated.

1. 16. Development of new approaches for tumor suppressor genes identification

   Författare :Jinfeng Li; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Tumor suppressor gene TSG ; Cloning of deleted sequences CODE ; Cloning of polymorphisms COP ; Cloning of identical sequences CIS ; Gene inactivation test GIT .;

   Sammanfattning : Development of tumor is a complex process involving multiple steps. New technologies for cloning and identifying genes playing critical role in cancer development are necessary. That is why we have focused our research on development of these approaches. LÄS MER

3. 17. From a candidate region to gene characterization : analysis of three new genes with respect to meningioma tumorigenesis

   Författare :Myriam Peyrard; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :meningioma; central nervous system; monosomy 22; tumor suppressor gene; ADTBI BAM22 gene; clathrin-coated vesicles; adaptin; assembly protein;

   Sammanfattning : Meningioma is a common and usually benign tumor arising from the meninges covering the central nervous system (CNS). The yearly incidence of symptomatic meningiomas is 1.2 cases per 100 000 individuals but autopsy findings reveal an occurrence ten times higher. LÄS MER

4. 18. Gating and modulation mechanism of voltage gated sodium channels

   Författare :Koushik Choudhury; Lucie Delemotte; Erik Lindahl; Philip Biggin; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Voltage gated sodium channels; Molecular dynamics simulation; π-helix; open state; Biologisk fysik; Biological Physics;

   Sammanfattning : Voltage-gated sodium channels (Nav channels) play an essential role in nerve impulse conduction in excitable cells. Thus, these channels are involved in several neurological and muscular disorders. Understanding their mechanism of functioning  is essential for designing drugs targeting them. LÄS MER

5. 19. Evaluation of microbial health risks associated with the reuse of source-separated humna urine

   Författare :Caroline Höglund; KTH; []
   Nyckelord :urine-separation; urine; wastewater systems; wastewater reuse; recycling; enteric pathogens; faecal sterols; indicator bacteria; hygiene risks; microbial persistence; microbial risk assessment; QMRA; fertiliser; crop;

   Sammanfattning : Human excreta contain plant nutrients and have the potentialto be used as a fertiliser in agriculture. Urine contributesthe major proportion of the nutrients (N, P and K) in domesticwastewater whereas faeces contribute a smaller amount andinvolves greater health risks if reused due to the possiblepresence of enteric pathogens. LÄS MER

7. 20. Polyelectrolytes and Polycomplexes in Biotechnology

   Författare :Maria Dainiak; Bioteknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; expanded bed adsorption.; affinity precipitation; Fab fragments; monoclonal antibodies; glyceraldehyde-3-phosphate dehydrogenase; misfolded protein; chaperone; poly N-ethyl-4-vinylpyridinium bromide ; poly methacrylic acid ; poly acrylic acid ; Key words: polyelectrolyte; polyelectrolyte complexes; Biotechnology; Bioteknik; Chemical technology and engineering; Kemiteknik och kemisk teknologi;

   Sammanfattning : Polyelectrolytes and polyelectrolyte complexes (PECs) are characterized by many useful properties that endow them with high potential in different areas of biotechnology. This thesis describes the development and analyses of some new systems and methods utilizing poly(acrylic acid) (PAA), poly(methacrylic acid) (PMA), poly (N-ethyl-4-vinylpyridinium bromide) (PEVP) and PMA-PEVP complexes. LÄS MER