Avancerad sökning

Hittade 3 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Aspects of diagnosis and treatment of hypopituitarism in adult life

    Författare :Helena Filipsson; Göteborgs universitet; []
    Nyckelord :hypopituitarism; pituitary; diagnosis; treatment; GHD; central hypothyroidism; genetic; idiopathic; ACTH insufficiency; discontinuation;

    Sammanfattning : Management of adult patients with hypopituitarism can improve with better char¬ac¬terisation of idiopathic pituitary insufficiency (IPI) and clearer diagnosis of central hy¬pothy¬roidism (CH). Moreover, optimised treatment strategies for glucocorticoid (GC) re¬placement therapy and of long-term growth hormone (GH) in GH deficiency (GHD) are needed. LÄS MER

  3. 2. Metabolic effects and long-term safety of childhood growth hormone treatment

    Författare :Anders Tidblad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The overall aim of this thesis was to investigate the metabolic effects and long-term safety of childhood growth hormone (GH) treatment. In order to achieve this aim, the different projects consist of a two-part clinical trial on metabolic features linked to GH physiology and GH treatment as well as two large population-based cohort studies with focus on the long-term cardiovascular and cancer risks in previously GH-treated patients. LÄS MER

  4. 3. Studies on the regulation and in vitro metabolic effects of leptin in children and adults

    Författare :Amira M I Elimam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Leptin; growth hormone; cortisol; Dexamethasone; insulin; fasting; total parenteral nutrition; meal timing; obese children; Prader Willi syndrome; adipocyte; lipolysis; lipogenesis.;

    Sammanfattning : Leptin is a protein hormone secreted by adipocytes, which binds to receptors in the brain to affect food intake and energy expenditure. The leptin receptor is a member of the cytokine receptor family and is widely distributed in the body suggesting a broader role for leptin. LÄS MER