Sökning: "Hypoxia tolerance"

Visar resultat 6 - 10 av 14 avhandlingar innehållade orden Hypoxia tolerance.

  1. 6. Mitochondrial efficiency : focus on dietary nitrate, hypoxia and exercise

    Författare :Tomas Schiffer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Metabolic efficiency affects weight control, generation of heat, exercise performance and health. The tiny radical nitric oxide (NO) targets several cellular components that can influence metabolic efficiency. NO is produced endogenously from L-arginine and molecular oxygen by specific NO-synthases. LÄS MER

  3. 7. The role of bacterial endotoxin in the immature brain

    Författare :Saskia Eklind; Göteborgs universitet; []
    Nyckelord :lipopolysaccharide; hypoxia-ischemia; immature; temperature; cerebral blood flow; blood glucose; inflammation; apoptosis; microarray; preconditioning;

    Sammanfattning : Aim: Epidemiological evidence suggests that infections may increase the vulnerability of the immature brain to further insults. The aim of this thesis was to investigate the role of bacterial endotoxin (lipopolysaccharide, LPS) on hypoxic-ischemic (HI) injury in the immature rat brain, and to evaluate possible underlying mechanisms of increased sensitivity. LÄS MER

  4. 8. Nitric oxide generation from nitroglycerin and other no-donors measured in the lung and studies on nitrate tolerance in the cardiovascular system

    Författare :Per Agvald; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Exhaled; nitric oxide; nitroglycerin; nitrite; temperature; tolerance; hypoxia;

    Sammanfattning : Nitroglycerin (GTN) and compounds referred to as nitrovasodilators or NOdonors are frequently used in the treatment of ischemic heart disease. The common mode of action for these drugs is liberation of nitric oxide (NO). Nitric oxide evokes relaxation of smooth muscle through activation of guanylate cyclase with subsequent formation of eGMP. LÄS MER

  5. 9. Hypoxia and auto resuscitation in the neonatal rodent with special reference to the sympatho-adrenal system

    Författare :Shi-Zeng Yuan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adrenal medulla; apnea; asphyxia; autoresuscitation; catecholamines; SIDS;

    Sammanfattning : Preterm infants exhibit irregular breathing with frequent episodes of apnea, which may be associated with cyanosis and bradycardia. Perinatal asphyxia causes a considerable amount of morbidity and mortality that occurs during early life. Studies of mechanisms responsible for perinatal asphyxia are therefore very important. LÄS MER

  7. 10. Physiology and pathophysiology of central adenosine A1 and A2A receptors

    Författare :Linda Halldner Henriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adenosine; A1 receptor; A2A receptor; knock-out mouse; in situ hybridization; receptor autoradiography; sleep; hypoxia-ischemia; behavior; motor activity; caffeine; tolerance;

    Sammanfattning : The aim of this thesis was to further investigate the individual roles of central adenosine A1 and A2A receptors in the physiological and pathophysiological effects of adenosine. In addition, the characteristics of different adenosine receptor ligands were studied. LÄS MER