Sökning: "cell membrane damage"
Visar resultat 1 - 5 av 122 avhandlingar innehållade orden cell membrane damage.
1. Pathogen entry mechanisms and endocytic responses to plasma membrane damage
Sammanfattning : Endocytosis is a fundamental cellular process by which cells transport material from the outside to the inside of the cell through the formation of membrane invaginations that bud off from the plasma membrane. This process is important for nutrient uptake, regulating cell surface receptors and the overall plasma membrane composition. LÄS MER
2. Cell Contacts and Airway Epithelial Damage in Asthma
Sammanfattning : Airway epithelial damage is commonly found in asthma patients. Epithelial damage was investigated with special reference to contacts between epithelial cells.Eosinophils, common in allergic asthma, secrete cationic proteins, particularly major basic protein (MBP). LÄS MER
3. Towards Pharmacological Treatment of Cystic Fibrosis
Sammanfattning : S-nitrosogluthatione is an endogenous substance, present at decreased levels in the lungs of CF patients and was recently found to induce mature CFTR in airway epithelial CF cell lines. We show that S-nitrosoglutathione in physiological concentrations increases the presence of ΔF508 CFTR in the cell membrane and induces cAMP dependent chloride transport in cystic fibrosis airway epithelial cells. LÄS MER
4. Imaging the molecular pathways of neurodegeneration : New pathologies of SCA7
Sammanfattning : Spinocerebellar Ataxia type 7 (SCA7) is a genetic neurodegenerative disease with lethal outcome that affects the cerebellum and retina of patients. This thesis focuses on characterising molecular pathological pathways that cause toxicity and cell death in SCA7. LÄS MER
5. Effects of reactive oxygen species on the cellular vacuolar apparatus
Sammanfattning : Reactive and potentially harmful oxygen species occur, and are continuously formed, in all cells of a living organism. Increased production of these metabolites are seen in a number of pathological states, for instance in inflammatory foci or during reoxygenation of ischemic tissue. LÄS MER