Sökning: "HEAVY-CHAIN"
Visar resultat 1 - 5 av 101 avhandlingar innehållade ordet HEAVY-CHAIN.
1. Transcription factors regulating the immunoglobulin heavy chain locus
Sammanfattning : The immunoglobulin heavy (IgH) chain locus is subject to somatic recombination and changes in gene expression in B lineage cells. Enhancers located in the 3' end of the locus may in part regulate these events. This work aimed at increasing the understanding of the function of one of these elements, the HS1,2 enhancer. LÄS MER
2. Evolutionary aspects of the immunoglobulin heavy chain constant locus
Sammanfattning : The human Ig heavy chain constant locus (IGHC) is composed of nine functional and two pseudo genes. Extensive polymorphism consisting of deletions, duplications and point mutations have been observed in this locus. LÄS MER
3. Regulation of germline transcription in the immunoglobulin heavy chain locus
Sammanfattning : During an immune response, activated B cells develop into high rate immunoglobulin (Ig) secreting plasma cells. They also switch from production of IgM to IgG, IgA or IgE. Specific isotypes of antibodies have functional and structural features that make them particularly well suited to defend against different types of pathogens. LÄS MER
4. Variability and adaptation in the contractile system of smooth muscle
Sammanfattning : This thesis examines the cellular and molecular mechanisms involved in the large diversity of the contractile properties in smooth muscle. Six studies, I-VI, are included. I: a slow smooth muscle (aorta) has a different nucleotide and phosphate dependence compared to a fast type (taenia coli). LÄS MER
5. The evolutionary study of the immunoglobulin heavy chain genes of a bony fish, rainbow trout (Oncorhynchus mykiss)
Sammanfattning : .... LÄS MER