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  1. 21. Cellular proteins binding to the HCV 5' and 3' UTRs

    Författare :Karin Spångberg; Ingemar Ernberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Hepatitis C virus; RNA-binding proteins; mRNA stability; translation; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Sammanfattning : Hepatitis C virus (HCV) is a worldwide health problem with more than 170 million people infected by the virus. About 80% become chronic carriers, which may result in hepatocellular carcinoma. The lack of an in vitro cell culture system that allows propagation of the virus has hampered the development of a vaccine or anti-viral drugs against HCV. LÄS MER

  3. 22. Blood Borne Viruses (HIV, HBV and HCV) among Participants of a Swedish Needle Exchange Program

    Författare :MARIANNE ALANKO BLOMÉ; Enheten för infektionssjukdomar; []
    Nyckelord :Hepatitis C virus HCV infection; Hepatitis B; HIV prevention; people who inject drugs; Needle exchange program; HBV vaccination;

    Sammanfattning : .... LÄS MER

  4. 23. Innate and adaptive cellular immunity in chronic HCV and HIV-1 infection

    Författare :Veronica D Gonzalez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HCV; HIV-1; co-infection; adaptive immunity; innate immunity; NK cell; NKT cell; CD4 T cell; CD8 T cell; IFNalpha; ribavirin; immune activation;

    Sammanfattning : Viral infections are initially countered by an innate immune response as a first line of defence followed by an adaptive immune response. However, certain viruses successfully evade cellular immune responses and establish chronic infection. LÄS MER

  5. 24. Generation of polyfunctional T cells against HCV by T cell redirection and vaccination

    Författare :Anna Pasetto; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The hepatitis C virus (HCV) is the major cause of liver disease and it is estimated that around 170 millions of people are infected worldwide. The available therapy is a combination of pegylated-interferon-alpha, ribavirin and since 2011, also NS3/4A protease inhibitors boceprevir and telaprevir. LÄS MER

  7. 25. Role of the 3'UTR in translation and stability of HCV and HPV mRNAs

    Författare :Lisa Wiklund; Laszlo Szekely; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Hepatitis C virus; Human Papillomavirus; 3’ untranslated region; AU-rich sequence; mRNA stability; translation; Biokemi; Biochemistry; Biokemi; Medical Virology; medicinsk virologi;

    Sammanfattning : Virus mRNAs can be divided into functional regions. The focus of this thesis will be to investigate the function of one of these regions, the 3’ untranslated region (UTR). The 3’UTR of HCV contains a U-rich element and the late 3’UTR of HPV-1 contains an AU-rich element. LÄS MER