Sökning: "Estrogen receptor beta"

Visar resultat 11 - 15 av 63 avhandlingar innehållade orden Estrogen receptor beta.

  1. 11. Molecular mechanisms of alternative estrogen receptor signaling

    Författare :Linda Björnström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogen is a key regulator of growth, differentiation and function in a broad range of target tissues, including the male and female reproductive tracts, mammary gland, bone, brain and the cardiovascular system. The biological effects of estrogen are mediated through estrogen receptor a (ERalpha) and estrogen receptor beta (ERbeta), which belong to a large superfamily of nuclear receptors that act as ligand-activated transcription factors. LÄS MER

  3. 12. Prevention of beta-cell dysfunction via targeting novel GPCRs in pancreatic islets

    Författare :Rajesh Kumar; Islet cell physiology; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type II Diabetes; GPCR; Pancreatic islets; Estrogen; Alpha-1 antitrypsin.;

    Sammanfattning : The primary aim of this thesis was to investigate the role of G protein coupled receptors (GPCRs) in insulin secretion and beta-cell survival. The second aim was to determine which pathway is involved in insulin release and beta-cell protection via GPCRs. LÄS MER

  4. 13. Estrogen receptor signalling in mammary epithelial cells

    Författare :Malin Hedengran Faulds; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ER; STAT5; mammary epithelial cell differentiation; EGF; DAX-1;

    Sammanfattning : The mammary gland is a complex tissue going through cycles of extensive proliferation and differentiation. Many hormones are involved in the regulation of development of the mammary gland, including estrogen, prolactin and epidermal growth factor (EGF). LÄS MER

  5. 14. Exploring the genome-wide impact of estrogen receptor alpha and estrogen receptor beta in breast and colon cancer cells

    Författare :Karin Edvardsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogen signaling is involved in the development and progression of breast cancer and is implicated to be protective in colon cancer. Estrogenic actions are conveyed through transcriptional regulation by ligand stimulated estrogen receptors (ERα and ERβ). LÄS MER

  7. 15. Signal transduction via estrogen receptors (ERs) and estrogen receptor-related receptors (ERRs)

    Författare :Katarina Pettersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogens influence post-natal development and function of the female reproductive system and other organs including bone and cardiovascular system. Estrogens are also involved in the development and growth of certain cancers in e.g. breast and uterine endometrium. LÄS MER