Sökning: "DAX-1"

Hittade 4 avhandlingar innehållade ordet DAX-1.

  1. 1. Estrogen receptor signalling in mammary epithelial cells

    Författare :Malin Hedengran Faulds; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; ER; STAT5; mammary epithelial cell differentiation; EGF; DAX-1;

    Sammanfattning : The mammary gland is a complex tissue going through cycles of extensive proliferation and differentiation. Many hormones are involved in the regulation of development of the mammary gland, including estrogen, prolactin and epidermal growth factor (EGF). LÄS MER

  2. 2. Modulation of Nuclear Receptor Signaling by RBR Ubiquitin Ligases

    Författare :Nina Gustafsson Sheppard; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Nuclear receptors (NRs) constitute a superfamily of transcription factors and play important roles in physiology. Transcriptional regulation by NRs can be modulated through interactions with various coregulators that activate or repress transcription through mediating receptor and chromatin modifications as well as communicating with the general transcription factor machinery. LÄS MER

  3. 3. Modulation of nuclear receptor activity by a unique class of corepressors

    Författare :Elin Holter; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Nuclear receptors; corepressors; transcription; intracellular localization.;

    Sammanfattning : Nuclear receptors comprise a unique family of transcription factors that are crucial regulators of gene expression involved in diverse physiological and developmental processes. The nuclear receptor field has undergone a very rapid development during the recent two decades due to the recognition of the importance of nuclear receptors as intracellular signal transmitters and pharmaceutical targets. LÄS MER

  4. 4. Transcriptional Regulation by the Nuclear Receptors Steroidogenic Factor-1 and Liver Receptor Homologue-1

    Författare :Anna Ehrlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Steroidogenic Factor-1 (SF-1) and Liver Receptor Homologue-1 (LRH-1) are transcription factors belonging to the nuclear receptor (NR) family. In the adrenal cortex and gonads, SF-1 governs the expression of multiple enzymes and transporters required for converting cholesterol to steroid hormones. LÄS MER