Sökning: "Epithelial ovarian cancer"

Visar resultat 11 - 15 av 53 avhandlingar innehållade orden Epithelial ovarian cancer.

1. 11. Early Diagnosis of Epithelial Ovarian Cancer - Analysis of Novel Biomarkers

   Författare :Björg Kristjansdottir; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epithelial Ovarian Cancer; Ovarian cyst fluid; Tumor biomarkers; Proteomics; Pelvic mass; Mass Spectometry; SELDI-TOF MS; iTRAQ;

   Sammanfattning : Early Diagnosis of Epithelial Ovarian Cancer - Analysis of Novel Biomarkers Björg Kristjánsdóttir Department of Obstetrics & Gynecology, Institute of Clinical Sciences at Sahlgrenska Academy, University of Gothenburg, Sweden ABSTRACT Background: Majority of epithelial ovarian cancer (EOC) is detected in advanced stage with bad prognosis and high mortality. Reliable diagnostic markers are lacking, pre-cancerous lesions in the more aggressive tumors are not clearly defined, vague or unspecific early symptoms, and the localization of the ovaries, deep in the pelvis contributes to late diagnose. LÄS MER

3. 12. Novel biomarkers associated with histotype and clinical outcome in early-stage ovarian carcinoma

   Författare :Hanna Engqvist; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovarian carcinoma; histotype-specific diagnosis and prognosis; molecular biomarker; outcome prediction; integrative analysis;

   Sammanfattning : Ovarian cancer is a collective name for multiple malignancies deriving from or involving the ovary, mainly comprising five histotypes of epithelial origin (clear-cell (CCC), endometrioid (EC), high-grade serous (HGSC), low-grade serous (LGSC), and mucinous carcinomas (MC)) with varying clinical (e.g. LÄS MER

4. 13. Heparan sulfate dependent cell signaling and associated pathophysiology : Implications in tumorigenesis and embryogenesis

   Författare :Tahira Batool; Jin-Ping Li; Aristidis Moustakas; Liliana Schaefer; Ingvar Ferby; Michael Welsh; Anders Malmström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparanase; Glucuronyl-C5 epimerase; Heparan Sulfate; Heparin; Lung Cancer; Cancer cell Singling; TGF-Beta; BMP; VEGF; Notch Signaling; Tumor growth; Metastasis; embryonic development; Medical Biochemistry; Medicinsk biokemi;

   Sammanfattning : Heparan sulfate proteoglycans (HSPGs) consist of a protein core to which several linear, negatively charged heparan sulfate (HS) chains are covalently attached. HSPGs are expressed on the cell surface and in the extra-cellular matrix (ECM) where they have diverse biological functions, for example co-receptor functions. LÄS MER

5. 14. Tight juntion in ovarian surface epithelium and epithelial ovarian tumors

   Författare :Yihong Zhu; Göteborgs universitet; []
   Nyckelord :junction; claudin; ovarian surface epithelium; epithelial ovarian tumor; TGF-?1;

   Sammanfattning : Epithelial ovarian cancer originating from ovarian surface epithelium (OSE) is the most lethal type of gynecological cancer among women worldwide. The poor understanding of the cellular and molecular events associated with ovarian carcinogenesis leads to difficulties in early diagnosis and in efficient treatment. LÄS MER

7. 15. Hormone concentrations during pregnancy and maternal risk of epithelial ovarian cancer

   Författare :Helena Schock; Eva Lundin; Annika Idahl; Renée Turzanski Fortner; Anne Zeleniuch-Jacquotte; Shelley S Tworoger; Umeå universitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; epithelial ovarian cancer; sex steroid hormones; IGF-I; placental GH; AMH; pregnancy; prospective study; patologi; Pathology;

   Sammanfattning : Background: The aim of this thesis was to study the relationship of pre-diagnostic circulating concentrations of sex steroid hormones (androgens, estradiol, 17-hydroxyprogesterone, and progesterone), growth factors (insulin-like growth factor-I (IGF-I), placental growth hormone (GH)), sex hormone binding globulin (SHBG), and anti-Müllerian hormone (AMH) with risk of epithelial ovarian cancer (EOC) overall, and by tumor invasiveness and histology. A longitudinal study was used to assess patterns of hormonal changes during a single pregnancy, and in two consecutive pregnancies. LÄS MER