Sökning: "EDSS"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet EDSS.

  1. 1. Longitudinal Models for Quantifying Disease and Therapeutic Response in Multiple Sclerosis

    Författare :Ana M. Novakovic; Mats O. Karlsson; Etienne Pigeolet; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; NONMEM; multiple sclerosis; cladribine; EDSS; item response theory; relapse rate; absolute lymphocyte count; total volume T2 lesions; burden of disease; power; sample size; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Treatment of patients with multiple sclerosis (MS) and development of new therapies have been challenging due to the disease complexity and slow progression, and the limited sensitivity of available clinical outcomes. Modeling and simulation has become an increasingly important component in drug development and in post-marketing optimization of use of medication. LÄS MER

  3. 2. Brain parenchymal fraction in healthy individuals and in clinical follow-up of multiple sclerosis

    Författare :Mattias Vågberg; Anders Svenningsson; Richard Birgander; Jonathan Gilthorpe; Anne-Marie Landtblom; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Brain parenchymal fraction; Neurofilament light; Glial fibrillary acidic protein; Brain atrophy; Multiple Sclerosis; Clinical follow-up;

    Sammanfattning : Background Multiple sclerosis (MS) is an autoimmune disease characterised by inflammatory damage to the central nervous system (CNS). Accumulated CNS injury can be quantified as brain atrophy, definable as a reduction in brain parenchymal fraction (BPF). BPF correlate with disability in MS and is used routinely as an endpoint in clinical trials. LÄS MER

  4. 3. Work ability in multiple sclerosis : the impact of immunomodulating treatments and adjusted working conditions

    Författare :Anne Wickström; Anders Svenningsson; Magnus Vrethem; Charlotte Dahle; Lars Forsgen; Fredrikson Sten; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Background Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease affecting the central nervous system (CNS) and is considered to be of autoimmune origin. The prevalence in Sweden is estimated to be about 1 in 500. LÄS MER

  5. 4. Cognitive function and neurophysiological correlates in relapsing-remitting multiple sclerosis

    Författare :Mathias Sundgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Impaired cognitive function is a frequent consequence of multiple sclerosis (MS). It negatively affects vocational status, treatment adherence, physical independence, competence in activities of daily life, rehabilitation potential, driving safety and quality of life. LÄS MER

  7. 5. Environmental Monitoring of Refuse Dump Leachate Toxicity in Fish

    Författare :Erik Noaksson; Lennart Balk; Louis J. Guillette Jr; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fiskar; miljögifter; Toxicology; Toxikologi;

    Sammanfattning : The global economy is driven by the consumption of goods and materials. Used products are often deposited on refuse dumps, making them potential point sources for all man-made chemicals. Water soaking through landfill waste results in a wastewater termed leachate. LÄS MER