Sökning: "Fredrikson Sten"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Fredrikson Sten.

  1. 1. Treatment with the monoclonal antibody rituximab in Multiple Sclerosis : a study based on an academic clinical trial

    Författare :Pierre de Flon; Anders Svenningsson; Martin Gunnarsson; Katarina Laurell; Sten Fredrikson; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple sclerosis; Rituximab; Cytokines; Immunological profile; Neurofilament light; Treatment satisfaction; neurologi; Neurology;

    Sammanfattning : Background: Multiple sclerosis (MS) is a chronic, inflammatory disease, affecting the central nervous system. A growing number of disease modifying treatment alternatives entails a need for an individualised risk-benefit- convenience analysis in the counselling of patients and methods to monitor the treatment effect, including markers for subclinical inflammation. LÄS MER

  2. 2. The significance of risk adjustment for the assessment of results in intensive care. : An analysis of risk adjustment models used in Swedish intensive care

    Författare :Lars Engerström; Sten M. Walther; Folke Sjöberg; Mats Fredrikson; Kathy Rowan; Linköpings universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : To study the development of mortality in intensive care over time or compare different departments, you need some kind of risk adjustment to make analysis meaningful since patient survival varies with severity of the disease. With the aid of a risk adjustment model, expected mortality can be calculated. LÄS MER

  3. 3. Risk-Adjustment for Swedish In-Hospital Trauma Mortality using International Classification of disease Injury Severity Score (ICISS) : issues with description and methods

    Författare :Robert Larsen; Folke Sjöberg; Ingrid Steinvall; Mats Fredrikson; Sten M. Walther; Søreide Eldar; Linköpings universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : IntroductionDifferent methods have been used to describe the epidemiology of trauma with varying results. Crude mortality outcome data differ significantly from risk-adjusted information. A previous standard method for risk-adjustment in trauma was the Injury Severity Score (ISS), although it has several shortcomings. LÄS MER

  4. 4. Immunological Mechanisms and Natalizumab Treatment in Multiple Sclerosis : Studies on lymphocytes, inflammatory markers and magnetic resonance spectroscopy

    Författare :Johan Mellergård; Magnus Vrethem; Jan Ernerudh; Charlotte Dahle; Sten Fredrikson; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Background: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease of the central nervous system (CNS), and a frequent cause of neurological disability among young adults. In addition to focal inflammatory demyelinated lesions, diffuse white matter pathology as well as a neurodegenerative component with accumulating axonal damage and gliosis have been demonstrated and contribute to MS disease characteristics. LÄS MER

  5. 5. Work ability in multiple sclerosis : the impact of immunomodulating treatments and adjusted working conditions

    Författare :Anne Wickström; Anders Svenningsson; Magnus Vrethem; Charlotte Dahle; Lars Forsgen; Fredrikson Sten; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Background Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease affecting the central nervous system (CNS) and is considered to be of autoimmune origin. The prevalence in Sweden is estimated to be about 1 in 500. LÄS MER