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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Regulation of Fibroblast Activity by Keratinocytes

    Författare :Daniel Nowinski; Mikael Ivarsson; Bengt Gerdin; Elof Ph D M.D. Eriksson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; conective tissue growth factor; interleukin-1; fibroblast; keratinocyte; wound healing; burns; Kirurgi; Surgery; Kirurgi;

    Sammanfattning : In the healing of cutaneous wounds, paracrine communication between keratinocytes and fibroblasts regulates cell differentiation, proliferation and synthesis of extracellular matrix. Deficient epidermal coverage, as seen in burn-wounds, frequently results in hypertrophic scars. LÄS MER

  3. 2. Interactions between Malignant Keratinocytes and Fibroblasts : Studies in Head and Neck Squamous Cell Carcinoma

    Författare :Malin Hakelius; Daniel Nowinski; Bengt Gerdin; Kristofer Rubin; Avni Abdiu; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coculture; extracellular matrix; interleukin-1 alpha; tumor stroma; differential gene regulation; innate response; Plastic Surgery; Plastikkirurgi;

    Sammanfattning : Carcinoma growth requires a supportive tumor stroma. The concept of reciprocal interactions between tumor and stromal cells has become widely acknowledged and the connective tissue activation seen in the malignant process has been likened to that of a healing wound. LÄS MER

  4. 3. Reconstruction of the alveolar process in cleft patients

    Författare :Fatemeh Jabbari; Daniel Nowinski; Agneta Marcusson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alveolar bone grafting; dental status; initial cleft size; dental restoration; unilateral cleft lip and palate; cleft lip and alveolus; primary periosteoplasty; facial growth;

    Sammanfattning : Background. The treatment of patients born with cleft lip and palate has been gradually modified over the years as the surgical procedures have developed and improved. Multidisciplinary team care has evolved and provided improved care with enhanced results. Clefts in the alveolus can be reconstructed by alveolar bone grafting or by periosteoplasty. LÄS MER

  5. 4. Articulation and velopharyngeal function in patients with cleft lip and/or palate : Outcome predictors

    Författare :Åsa Okhiria; Daniel Nowinski; Yvonne Wren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cleft lip and palate; cleft width; cleft type; surgical technique; articulation; velopharyngeal function; international adoption;

    Sammanfattning : Cleft lip and/or palate is the most common congenital craniofacial malformation, requiring multidisciplinary treatment, including surgery and often speech therapy. Palatal surgery restores the anatomical barrier between the oral and nasal cavities as well as the palatal function needed for normal speech. LÄS MER

  7. 5. Keratinocytes and Adipose-derived mesenchymal stem cells : The heir and the spare to regenerative cellular therapies for difficult-to-heal skin wounds

    Författare :Hady Shahin; Ahmed Taher Elserafy; Moustafa Elmasry; Folke Sjöberg; Ingrid Steinvall; Daniel Nowinski; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Keratinocytes; ATMP; Bio-production; Adipose-derived mesenchymal stem cells; Wound healing;

    Sammanfattning : Cell-based therapy is considered as Advanced Therapy Medicinal Product, (ATMP), which had increasingly stricter regulations in the last decade. The cells must be produced according to the ‘Guidelines on Good Manufacturing Practice (GMP) specific to Advanced Therapy Medicinal Products’, adopted by the European Medicines Agency (EMA). LÄS MER