Sökning: "Transactivation domain"

Visar resultat 1 - 5 av 47 avhandlingar innehållade orden Transactivation domain.

  1. 1. Transcriptional regulation of the Epstein-Barr virus latent membrane protein 1 gene in B cells

    Författare :Weiwen Yang; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; B-cell; transformation; LMP1; LRS; EBNA2; transcription; transactivation; repression; histone deacytylation;

    Sammanfattning : Epstein-Barr Virus (EBV) is a ubiquitous human B-lymphotrobic herpesvirus that latently infects over 90 percent of the world´s population. EBV infection is usually benign in healthy people. LÄS MER

  2. 2. THE ANDROGEN RECEPTOR GGN POLYMORPHISM. Genetic and functional analyses

    Författare :Kristina Lundin; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Functional domain; Genetic predisposition; Reproductive function; Sex hormone; Transactivation function; Repeat; Polymorphism; Androgen receptor; Transcription factor; Medicin människa och djur ; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Male sex development and reproductive function is regulated by androgens acting via the androgen receptor (AR). The AR harbours two polymorphic repeats of CAG and GGN triplets, encoding glutamines and glycines, respectively. LÄS MER

  3. 3. The life and death of the notch intracellular domain

    Författare :Camilla Öberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : The Notch signaling pathway is an evolutionarily conserved way of communicating between cells that contact each other. Notch is a single-transmembrane spanning receptor that interacts with single-transmembrane spanning ligands on adjacent cells. In vertebrates the Notch family of receptor consists of four members: Notch1 to Notch4. LÄS MER

  4. 4. Gene regulation by the glucocorticoid receptor : Post-DNA binding mechanisms of transcriptional activation

    Författare :Tova Almlöf; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Gene activation; Glucocorticoid receptor; Nuclear receptor; Transactivation domain; Transcription; Transcription factor; Yeast;

    Sammanfattning : The glucocorticoid receptor (GR) is a ligand-inducible transcription factor thatbelongs to the nuclear receptor family. The GR has important functions in cellulardifferentiation, development and metabolism in higher eukaryotes. LÄS MER

  5. 5. Chromatin remodeling complexes involved in gene activation by the glucocorticoid receptor

    Författare :Annika Wallberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : The glucocorticoid receptor (GR) belongs to a large family of ligand-inducible nuclear receptors and consists of a ligand binding domain, a DNA binding domain and transactivation domains. The main transcriptional activation domain, c I, is located in the N-terminus of the receptor. The r I c represents the minimal core activation domain of rl. LÄS MER