Sökning: "Carrageenan"

Visar resultat 6 - 10 av 28 avhandlingar innehållade ordet Carrageenan.

1. 6. Bilateral neurogenic mechanisms following acute unilateral inflammation

   Författare :Indre Bileviciute-Ljungar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :bilateral changes; host defence reaction; contralateral treatment; dorsal root reflexes; cross-spinal reflexes; substance P; neurokinin A; calcitonin gene-related peptide; neuropeptide Y; nociception; inflammation; carrageenan; edema; hindpaw withdrawal latency; microdialysis; hot-plate test; Randall Selitto test;

   Sammanfattning : The contribution of neurogenic mechanisms to inflammation has been extensively studied during the last decade, but provides no clear understanding of the bilateral changes commonly seen following unilateral stimulation. This work demonstrates that bilateral neurogenic mechanisms are a part of general host defence reactions following acute unilateral challenge, for the first time revealing that local anaesthetics applied contralaterally, might be used for therapeutic purposes in relieving pain and inflammation. LÄS MER

3. 7. Studies on the role of NGF in arthritis-induced pain transmission using gait and weight bearing as outcome measures

   Författare :Kristina Ängeby Möller; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Pain is one of the most common reasons for seeking healthcare, with approximately forty percent of those suffering from chronic pain having joint pain. Osteoarthritis is the most common cause of joint pain, but currently there are few treatments available. LÄS MER

4. 8. Effects of polyelectrolyte conformation, charge density and ion specificity in polyelectrolyte and polyelectrolyte-drug interaction

   Författare :Andreas M. Hugerth; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Physical and Inorganic Pharmaceutical Chemistry; fysikalisk och oorganisk farmaceutisk kemi;

   Sammanfattning : The central theme is how the structural characteristics of sulphated polyelectrolytes and theirinteraction with counter- and coions determine the degree of polyelectrolyte self-association (gelformation), interaction with oppositely charged polyelectrolyte and polyelectrolyte-amphiphilic druginteraction in protolytic solvent medium. Such knowledge is essential for understanding and regulatingthe interaction between polyelectrolytes as well as between polyelectrolytes and a drug substance in apharmaceutical formulation and for its fate in the human organism. LÄS MER

5. 9. Studies of carbohydrate structure, properties and interactions by nmr spectroscopy

   Författare :Eric Morssing Vilén; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : In this thesis the structure, properties and interactions of different types of carbohydrates were investigated by NMR spectroscopy. The structures of kappa- (κ) and kappa/mu- (κ/μ) carrageenan oligosaccharides were analyzed by studying the hydroxy protons. LÄS MER

7. 10. Behavioural and neurochemical effects and changes in gene expression in inflammatory and neuropathic pain

   Författare :Eva Schött; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Inflammatory pain; neuropathic pain; pain-related behaviour; weight bearing; preemptive analgesia; immediate early genes; substance P; dynorphin; cholecystokinin; microdialysis;

   Sammanfattning : Chronic pain is a common clinical problem, which causes great suffering, and there is a great need for better analgesic drugs and strategies to counteract the transition of acute pain into chronic pain states. In studies of neurochemical mechanisms in animal models of chronic pain it is important to study also the development of spontaneous pain-related behaviour and sensory abnormalities (i. LÄS MER