Sökning: "CILP"
Hittade 3 avhandlingar innehållade ordet CILP.
1. Identification and characterization of a novel cartilage gene product CILP, which is an early indicator of osteoarthritis
Sammanfattning : The aim of this work was to study alterations in the matrix composition of human articular cartilage in different stages of osteoarthritis and to isolate and characterize one of the proteins that is altered in the osteoarthritic process. The metabolism of articular cartilage in different stages of osteoarthritis including early asymptomatic OA was monitored in a culture system of metabolically labeled cartilage explants. LÄS MER
2. Proinflammatory and antigen-specific CD4+ T cells in rheumatoid arthritis
Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease primarily affecting peripheral joints. In this thesis work we aimed to increase the knowledge about proinflammatory and antigen-specific CD4+ T cell subsets involved in RA pathogenesis and I also investigated the effect of T cell directed therapy (abatacept) on CD4+ T cell subsets. LÄS MER
3. The T cell phenotype and receptor repertoire in different stages of rheumatoid arthritis : an immunological timeline
Sammanfattning : Rheumatoid arthritis (RA) is a systemic autoimmune disease, characterized by symmetrical inflammation in hands and feet. Antibodies recognizing citrullinated protein (ACPA) and/or rheumatoid factor (RF) are found in most patients and associates with a worse prognosis. Genetic predisposition (i.e. LÄS MER