Sökning: "CD27-CD70"

Hittade 2 avhandlingar innehållade ordet CD27-CD70.

1. 1. Immune activation during HIV-1 infection : implication for B cell dysfunctions and therapy monitoring

   Författare :Angelo De Milito; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV; B cell memory; hypergammaglobulinemia; immune activation; Fas-FasL; CD27-CD70;

   Sammanfattning : Aberrant activation of cells of the immune system plays a major role in the pathogenesis of HIV infection. The major aims of the thesis were: (a) to measure the effects of current antiretroviral therapy on immune activation through the analysis of soluble activation markers; (b) to evaluate the extent of T and B cell immune activation in relation to immunological and virological parameters; (c) to analyse the T-B cell molecular pathway leading to hyperactivation of B cells and loss of B cell function. LÄS MER

3. 2. Regulation of antibody production in immunocompromised patients

   Författare :Anna Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hypergammaglobulinemia; specific antibodies; memory B- cells; microenvironment;

   Sammanfattning : The aim of this thesis was to study B-cell function and the regulation of specific antibody (Abs) production in immunocompromised individuals. As models, we have studied children with acute lymphoblastic leukaemia (ALL) and patients with IRV-I infection. LÄS MER