Sökning: "Hypergammaglobulinemia"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet Hypergammaglobulinemia.

  1. 1. Regulation of antibody production in immunocompromised patients

    Författare :Anna Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hypergammaglobulinemia; specific antibodies; memory B- cells; microenvironment;

    Sammanfattning : The aim of this thesis was to study B-cell function and the regulation of specific antibody (Abs) production in immunocompromised individuals. As models, we have studied children with acute lymphoblastic leukaemia (ALL) and patients with IRV-I infection. LÄS MER

  3. 2. Immune activation during HIV-1 infection : implication for B cell dysfunctions and therapy monitoring

    Författare :Angelo De Milito; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV; B cell memory; hypergammaglobulinemia; immune activation; Fas-FasL; CD27-CD70;

    Sammanfattning : Aberrant activation of cells of the immune system plays a major role in the pathogenesis of HIV infection. The major aims of the thesis were: (a) to measure the effects of current antiretroviral therapy on immune activation through the analysis of soluble activation markers; (b) to evaluate the extent of T and B cell immune activation in relation to immunological and virological parameters; (c) to analyse the T-B cell molecular pathway leading to hyperactivation of B cells and loss of B cell function. LÄS MER

  4. 3. Mechanisms underlying impaired humoral immunity in primary and chronic HIV-1 infection

    Författare :Kehmia Titanji; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1 infection; HIV-2 infection; B cells; primary HIV-1 infection; immune activation; hypergammaglobulinemia; long-term humoral immunity; antiretroviral therapy;

    Sammanfattning : B cells of HIV-1-infected patients have both phenotypic and functional dysfunctions which may be important in HIV-1 pathogenesis. Immune activation during HIV infection is an essential part of the body s defense against the virus, but may be the root cause of B cell dysfunctions. LÄS MER

  5. 4. TRIM21/ Ro52 in B cell pathology

    Författare :Susanna Brauner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease affecting 0.2% of the population. Several B cell aberrances have been linked to pSS, such as autoantibody production, hypergammaglobulinemia and B cell associated genetic polymorphisms. In addition, pSS patients display a 16 fold increased risk to develop B cell lymphomas. LÄS MER

  7. 5. Identification of candidate genes involved in Mercury Toxicokinetics and Mercury Induced Autoimmunity

    Författare :Hammoudi Alkaissi; Per Hultman; Said Havarinasab; Peter Söderkvist; Jesper Bo Nielsen; Johan Rönnelid; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : BACKGROUND: Autoimmune diseases require the involvement and activation of immune cells and occur when the body builds up an immune response against its own tissues. This process takes place due to the inability to distinguish self-antigen from foreign antigen. Systemic autoimmunity represents an important cause of morbidity and mortality in humans. LÄS MER