Sökning: "Angelo De Milito"

Hittade 1 avhandling innehållade orden Angelo De Milito.

1. 1. Immune activation during HIV-1 infection : implication for B cell dysfunctions and therapy monitoring

   Författare :Angelo De Milito; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HIV; B cell memory; hypergammaglobulinemia; immune activation; Fas-FasL; CD27-CD70;

   Sammanfattning : Aberrant activation of cells of the immune system plays a major role in the pathogenesis of HIV infection. The major aims of the thesis were: (a) to measure the effects of current antiretroviral therapy on immune activation through the analysis of soluble activation markers; (b) to evaluate the extent of T and B cell immune activation in relation to immunological and virological parameters; (c) to analyse the T-B cell molecular pathway leading to hyperactivation of B cells and loss of B cell function. LÄS MER