Sökning: "BALB c mice"

Visar resultat 11 - 15 av 51 avhandlingar innehållade orden BALB c mice.

  1. 11. Investigation of T cell driven arthritis induced by mannan in ZAP70 mutated SKG mice

    Författare :Simon Guérard; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmune diseases are particularly challenging to study in human due to their complex multifactorial nature. In rheumatoid arthritis (RA), self-reactivity directed against joints leads to pain, tissue destruction and eventually invalidity if left untreated. LÄS MER

  3. 12. Fcγ-receptors in systemic autoimmune conditions : lessons from murine mercury-induced autoimmunity

    Författare :Klara Martinsson; Per Hultman; Karin Cederbrant; Johan Rönnelid; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : In this thesis we investigated the role of activating (FcγRI, FcγRIII) and inhibitory (FcγRIIB) Fcγ-receptors on systemic autoimmunity using two mouse strains, DBA/1 (H-2q) and BALB/c mice (H-2d), susceptible to induction of autoimmunity by mercury (Hg).Fc-receptors for IgG (FcγR) link cellular and humoral immune responses, control the balance between activating and inhibitory immune responses and are important in the development of several autoimmune diseases. LÄS MER

  4. 13. Heavy Metal Superantigen : Genetic Regulation of Lymphocyte Activation by HgC12

    Författare :Yun Jiang; Peter Mathieson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

    Sammanfattning : Injections of subtoxic doses of HgCl2 (mercuric chloride) cause a systemic autoimmune disease in genetically predisposed rats and mice. My work was designed to elucidate how HgCl2 induces lymphocyte activation and how the response to HgCl2 is regulated in susceptible and resistant strains. LÄS MER

  5. 14. Modulation of immune responses in murine collagen induced arthritis

    Författare :Fredrik Bäckström; Göteborgs universitet; []
    Nyckelord :Experimental arthritis; type II collagen; immunomodulation; oral tolerance;

    Sammanfattning : Murine collagen-induced arthritis (CIA) is the most common model for studying human rheumatoid arthritis (RA). Autologous or heterologous type II collagen (CII) emulsified in Freund´s complete adjuvant induces arthritis in susceptible mice, which is histopathologically similar to RA. LÄS MER

  7. 15. Brain neurotrophin levels and mouse behavior : relationship to environmental influences

    Författare :Shun-Wei Zhu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Environmental Enrichment; Intermittent Individual Housing; Physical Exercise; Anxiety; NGF; BDNF; Dorsal Hippocampus; Ventral Hippocampus;

    Sammanfattning : All normal functions over the lifetime of an animal are based on a dynamic balance of at least three fundamental elements: brain, environment and behaviour. This thesis investigated different aspects of these three elements and revealed novel interactions of brain neurotrophins, environmental influences and emotional behaviour in mice. LÄS MER