Sökning: "Ventral Hippocampus"

Visar resultat 1 - 5 av 34 avhandlingar innehållade orden Ventral Hippocampus.

  1. 1. On the Mechanisms Behind Hippocampal Theta Oscillations : The role of OLMα2 interneurons

    Författare :Sanja Mikulovic; Richardson Leao; Klas Kullander; Stefan Remy; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hippocampus; interneuron; optogenetics; theta oscillations; anxiety;

    Sammanfattning : Theta activity is one of the most prominent rhythms in the brain and appears to be conserved among mammals.  These 4-12 Hz oscillations have been predominantly studied in the dorsal hippocampus where they are correlated with a broad range of voluntary and exploratory behaviors. LÄS MER

  3. 2. Brain neurotrophin levels and mouse behavior : relationship to environmental influences

    Författare :Shun-Wei Zhu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Environmental Enrichment; Intermittent Individual Housing; Physical Exercise; Anxiety; NGF; BDNF; Dorsal Hippocampus; Ventral Hippocampus;

    Sammanfattning : All normal functions over the lifetime of an animal are based on a dynamic balance of at least three fundamental elements: brain, environment and behaviour. This thesis investigated different aspects of these three elements and revealed novel interactions of brain neurotrophins, environmental influences and emotional behaviour in mice. LÄS MER

  4. 3. Modulation of acetylcholine release by serotonergic 5-HT1A and 5-HT1B receptors : a microdialysis study in the awake rat

    Författare :Xiao Jing Hu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Microdialysis; Acetylcholine; Serotonin; 5-HT1A receptor; 5-HT1B receptor; Frontal cortex; Ventral hippocampus;

    Sammanfattning : The aim of the thesis was to investigate the effects of the 5-HT1A receptor antagonist robalzotan (NAD-299) and the 5-HT1B receptor antagonist NAS-181 ((R)-(+)-2-(3-morpholinomethyl-2Hchromen-8-yl) oxymethyl-morpholine methanesulfonate) on cholinergic, glutamatergic and GABAergic neurotransmission in the rat brain in vivo. The extracellular levels of acetylcholine (ACh), glutamate (Glu) and GABA were monitored by microdialysis in the frontal cortex (FC) and ventral hippocampus (VHipp) in separate groups of awake rats. LÄS MER

  5. 4. Hippocampal galanin and acetylcholine in spatial learning

    Författare :Pär A Schött; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hippocampus; galanin; acetylcholine; memory and learning; swim maze; microinjections; HPLC;

    Sammanfattning : The aim of the present thesis was to study how the neuropeptide galanin affects the neurochemistry and functional activity of the cholinergic septohippocampal projection, which plays a pivotal role in learning and memory. This cholinergic system is strongly impaired in Alzheimer's disease and in age-related dementias. LÄS MER

  7. 5. In vitro and postmortem studies of the brain opioid system : association to opiate dependence

    Författare :Parisa Zarnegar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Opioid system; brain; gene expression; amygdala; hippocampus; opiate dependence;

    Sammanfattning : Opioids such as heroin are highly addictive illicit drugs. The μ opioid receptor (MOR) plays a central role in mediating the effects of opiates and related opioid. LÄS MER