Sökning: "Anti-tumor activity"
Visar resultat 16 - 20 av 59 avhandlingar innehållade orden Anti-tumor activity.
16. Revealing the secrets of MARCO : a target for cancer immunotherapy
Sammanfattning : Our immune system protects us from infectious agents and sustains the homeostasis in our body. However, the immune system can also play a role in initiation and progression of diseases such as autoimmune diseases and cancer. Cancer is still one of the leading causes for death worldwide and inflammation became one of the hallmarks of cancer. LÄS MER
17. Selective induction of apoptosis in tumors by small molecules reactivating p53
Sammanfattning : Lesions in the p53 pathway that inactivate p53 tumor suppression function occur with extremely high frequency in cancer, targeting almost all tumors regardless of patient age or tumor type. This study is aimed at developing approaches for the selective elimination of tumors carrying defects in the p53 pathway, namely protection of p53 from degradation by its own destructor HDM2 in wild type p53-carrying tumors and refolding of p53 by small molecules in mutant p53-containing tumors. LÄS MER
18. Targeting HER2-expressing tumors with potent drug conjugates and fusion toxins based on scaffold proteins
Sammanfattning : Targeted therapy is an emerging treatment for a variety of cancers. Small- sized scaffold proteins are an alternative to conventional antibody-based targeting molecules. LÄS MER
19. Uveal melanoma and macular degeneration : molecular biology and potential therapeutic applications
Sammanfattning : Uveal melanoma is the most common primary intraocular malignant tumor in adults with 30% to 50% of patients that ultimately succumb to metastatic disease, mainly to the liver. Although new diagnostic and therapeutic tools have been developed during the most recent years, only the eye conservation rate has been achieved, while the survival rate remains poor. LÄS MER
20. Regulation of human thioredoxin and glutaredoxin systems by oxidation and S-nitrosylation
Sammanfattning : The homeostasis of intracellular redox status has a crucial role in the cell survival and different processes such as DNA synthesis, gene expression, enzymatic activity, etc. This homeostasis is achieved via an intense balance between pro-oxidants and anti-oxidants. LÄS MER
