Sökning: "5-HT2A receptors"

Visar resultat 21 - 25 av 26 avhandlingar innehållade orden 5-HT2A receptors.

  1. 21. Estrogen receptor gene activity within the brain and the relation to psychiatric disorders : mapping and function

    Författare :Marie Österlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :steroid hormone; ER system; in situ hybridization; rnRNA; ER serotonin; depression; affective disorders;

    Sammanfattning : Estrogens have for a long time been known to regulate neuroendocrine functions in the central nervous system (CNS), primarily related to reproduction. In recent years estrogens have been found to also modulate many other brain functions, for example mood and cognition. LÄS MER

  3. 22. Novel pharmacological treatment alternatives for schizophrenia

    Författare :Charlotte Wiker; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Antipsychotic drugs are commonly divided into typical (first generation) and atypical (second generation) antipsychotic drugs. Clinically effective doses of typical antipsychotic drugs generate a striatal dopamine D2 receptor occupancy of about 70 80%, approaching a level that is associated with a high risk of extrapyramidal side effects. LÄS MER

  4. 23. Bioactive Compounds from the Marine Sponge Geodia barretti : Characterization, Antifouling Activity and Molecular Targets

    Författare :Martin Sjögren; Lars Bohlin; Per Jonsson; Anna-Karin Borg-Karlsson; Uppsala universitet; []
    Nyckelord :Pharmacognosy; Geodia barretti; barettin; secondary metabolites; settling inhibition; Balanus improvisus; analogs; 5-HT; Farmakognosi;

    Sammanfattning : The marine sponge Geodia barretti produces a range of secondary metabolites. Two of these compounds were isolated and elucidated guided by their ability to inhibit settlement of cypris larvae of the barnacle Balanus improvisus. LÄS MER

  5. 24. In vitro cellular models for neurotoxicity studies : neurons derived from P19 cells

    Författare :Dina Popova; Jacobsson Stig O.P.; Anna Forsby; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurotoxicity; Neuronal cell culture; P19 cells; SH-SY5Y cells; βIII-tubulin; Methylmercury; Okadaic acid; Acrylamide; MDMA; Piperazine-derived designer drugs.;

    Sammanfattning : Humans are exposed to a variety of chemicals including environmental pollutants, cosmetics, food preservatives and drugs. Some of these substances might be harmful to the human body. LÄS MER

  7. 25. On the mechanisms of action of atypical antipsychotic drugs : an experimental study

    Författare :Peter Hertel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :antipsychotic drugs; dopamine; serotonin; medial prefrontal cortex; dorsal raphe nucleus; risperidone; clozapine; idazoxan; [alpha]2 adrenoceptors; conditioned avoidance; catalepsy;

    Sammanfattning : A majority of schizophrenic patients respond to classical neuroleptic drugs which are believed to act largely via blockade of dopamine (DA) D2 receptors in limbic structures. However, a significant proportion do not respond to conventional D2 receptor blocking drugs or show a rather incomplete therapeutic effect, particularly on negative and cognitive symptoms. LÄS MER