Sökning: "heme biosynthesis"

Visar resultat 6 - 10 av 25 avhandlingar innehållade orden heme biosynthesis.

  1. 6. Iron in Haem Biosynthesis. Structural Studies of Ferrochelatase and Frataxin

    Författare :Tobias Karlberg; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Naturvetenskap; Natural science; Molekylär biofysik; Molecular biophysics; Biomedicinska vetenskaper; Biomedical sciences; protein crystallography; ferrochelatase; haem biosynthesis; iron; frataxin;

    Sammanfattning : Ferrochelatase catalyses the synthesis of heme by inserting Fe(II) into protoporphyrin IX. The structure of ferrochelatase from yeast has been determined (2.4 Å). The structure is homodimeric with each of the monomer made up of two Rossmann type domains with an active-site cleft between them. LÄS MER

  3. 7. Structure and mechanism of iron and magnesium chelatases - at the heme-chlorophyll branch-point

    Författare :Michel Fodje; Lunds universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; pi-helix; secondary structure; AAA; porphyrin metallation; chelatase; Molekylär biofysik;

    Sammanfattning : Tetrapyrroles are synthesised through a single branched biosynthetic pathway. Heme and chlorophyll are synthesised from the common intermediate protoporphyrin IX at the heme-chlorophyll branch-point. LÄS MER

  4. 8. Evolution of biological systems linked to complex cell architectures in Planctomycetota

    Författare :Emil Hägglund; Siv Andersson; Damien Devos; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Planctomcyetota; Cellular complexity; Gemmataceae; Phagocytocis; Serine Threonine kinase; Anammox; Hydrazine Synthase; Hydroxylamine oxidoreductase; Heme biosynthesis; Phylogenetics; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Sammanfattning : The eukaryotic cells have a nucleus and membrane-enclosed organelles for functions such as energy production, whereas the prokaryotic cells have a cell wall but no intracellular membrane-bound structures. Species of the Planctomycetota phylum are classified as bacteria but have diverse and complex cell architectures. LÄS MER

  5. 9. 5-Lipoxygenase : studies on the active site iron, and on the stimulatory factors Ca2+ and ATP

    Författare :Tove Hammarberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :non-heme iron centre; ATP binding; Ca2 binding; C2 domain;

    Sammanfattning : Human 5-lipoxygenase (5LO) is a monomeric non-heme iron enzyme, which catalyses the first two steps in the biosynthesis of leukotrienes: oxygenation of arachidonic acid to yield 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid (5-HPETE) and the subsequent dehydration to form the unstable epoxide intermediate 5(S)-trans-5,6-oxido7,9-trans-11,14-cis-eicosatetraenoic acid. The latter compound (leukotriene A4), is the precursor of the biologically active leukotrienes B4, C4, D4 and E4, which are regarded as critical mediators in asthma and other inflammatory and allergic disorders. LÄS MER

  7. 10. Tetrapyrrole synthesis in Bacillus subtilis

    Författare :Mats Hansson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : This thesis describes tetrapyrrole synthesis in the aerobic Gram positive bacterium Bacillus sub-tilis. Tetrapyrroles such as heme of a-, b-, c-, d- and o-type can be synthesised in this organism. In addition, there is strong evidence for the presence of the tetrapyrrole siroheme in B. subtilis. LÄS MER