Sökning: "cDNA array"
Visar resultat 1 - 5 av 25 avhandlingar innehållade orden cDNA array.
1. Genetic Profiling in Soft Tissue Sarcoma
Sammanfattning : Soft tissue sarcomas (STS) are a heterogeneous group of highly malignant mesenchymal tumors that account for ~1% of all malignancies. Frequent heterogeneity and pleomorphism along with suboptimal diagnostic reproducibility and insufficient prognostic markers make clinical management of these tumors difficult. LÄS MER
2. Functional aspects on the Epstein-Barr virus nuclear antigen 5
Sammanfattning : The Epstein-Barr virus (EBV) infects resting B-cells. This leads to an EBV driven transformation of the resting B-cell into a cell with an activated B-cell phenotype that proliferates indefinitely in vitro. Epstein-Barr Nuclear antigen 5 (EBNA5) is one out of six EBV encoded protein involved in transformation of resting B-cell. LÄS MER
3. Development and Application of Human Chromosome 22 Genomic Microarray : Chromosome 22-Associated Disorders Analyzed by Array-Based Comparative Genomic Hybridization
Sammanfattning : The array-based form of comparative genomic hybridization (array-CGH) is a new methodology that has shown to be of significant importance. This thesis focuses on the development of array-CGH with the aim to define candidate regions/genes on chromosome 22 in a wide spectrum of cancer-related conditions. LÄS MER
4. Molecular Characterization of Genomic Amplifications in Pancreatic Cancer
Sammanfattning : Pancreatic cancer includes multiple histologic subtypes that show large differences in their clinical and biological characteristics. Despite this diversity, more than 85% of the neoplasms in the organ are malignant ductal adenocarcinomas, which are the focus of the present thesis. LÄS MER
5. Microarray-Based Comparative Genomic Hybridization in Neurofibromatoses and DiGeorge Syndrome
Sammanfattning : Microarray-based comparative genomic hybridization (array-CGH) has emerged as a versatile platform with a wide range of applications in molecular genetics. This thesis focuses on the development of array-CGH with a specific aim to approach disease-related questions through improved strategies in array construction and enhanced resolution of analysis. LÄS MER